Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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Research Abstract |
We tried to identify androgen-regulated miRNAs and ncRNAs(Non-coding RNAs) in prostate cancer cell. First, We found several miRNAs are situated in the vicinity of AR binding sites we identified by ChIP-chip analysis. We also identified androgen responsive miRNAs and ncRNAs by large scale screening such as CAGE or short RNA sequence. Notably, we showed miR-148a is a primary androgen regulated miRNA strongly expressed in prostate cancer cells. Furthermore, we also found MiR-148a promotes prostate cancer cell proliferation.
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