| Project/Area Number |
21790306
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
YAMAMICHI Nobutake The University of Tokyo, 医学部附属病院, 助教 (30463897)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 胃癌 / 腸上皮化生 / エピジェネティクス / 消化管分化 / Cdx2 / SWI / SNF複合体 / Brm / miRNA / SWI/SNF複合体 / Cathepsin E |
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| Research Abstract |
The histologic type of gastric cancer is quite important for prediction of the patient's prognosis, evaluating the risk of invasion and/or metastasis, selection of the anti-tumor therapy, etc. Based on our recent study showing a correlation between Brm-deficiency and undifferentiated status of gastric cancer, we analyzed the expression of villin gene and found that Brm-type chromatin-remodeling SWI/SNF complex cooperatively regulates villin expression with Cdx2. Brm-deficiency in gastric canceration should influence expression of many gastrointestinal genes regulated by Cdx2, a transcription factor essential for intestinal development and homeostasis. It is strongly suggested that the correlation between Brm-deficiency and various histologic features of gastric cancer is based on the interaction with Cdx2 and the Brm-type SWI/SNF complex.
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