The study of the molecular mechanism of sex-related psychiatric disease
| Project/Area Number |
21790308
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | The University of Tokushima (2010)
The University of Tokyo (2009) |
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Principal Investigator |
MATSUMOTO Takahiro The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 准教授 (70447374)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | うつ病 / 性ホルモン / 性ステロイドホルモン / 核内レセプター / 精神神経疾患 / 転写 |
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| Research Abstract |
To study the role of sex hormones in life, we generated triple receptors (AR and ER a/b) knockout (TKO) mice. TKO male mice were born healthy but exhibited increased anxiety-like behavior with lowered post-synaptic serotonin-1A receptor in the forebrain. These data provide genetic evidence that sex steroid hormones are dispensable for the viability, but exert an anxiolytic effect via serotonin-1A receptor in males.
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] Distinct function of 2 chromatin remodeling complexes that share a common subunit, Williams syndrome transcription factor (WSTF).2009
Author(s)
Yoshimura K., Kitagawa H., Fujiki R., Tanabe M., Takezawa S., Takada I., Yamaoka I., Yonezawa M., Kondo T., Furutani Y., Yagi H., Yoshinaga S., Masuda T., Fukuda T., Yamamoto Y., Ebihara K., Li DY., Matsuoka R., Takeuchi JK., Matsumoto T., Kato S.
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Journal Title
Proc Natl Acad Sci USA 106
Pages: 9280-9285
Related Report
Peer Reviewed
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