The study of the molecular mechanism of sex-related psychiatric disease

• Project/Area Number: 21790308
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pathological medical chemistry
• Research Institution: The University of Tokushima (2010); The University of Tokyo (2009)
• Principal Investigator: MATSUMOTO Takahiro The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 准教授 (70447374)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: うつ病 / 性ホルモン / 性ステロイドホルモン / 核内レセプター / 精神神経疾患 / 転写

Research Abstract

To study the role of sex hormones in life, we generated triple receptors (AR and ER a/b) knockout (TKO) mice. TKO male mice were born healthy but exhibited increased anxiety-like behavior with lowered post-synaptic serotonin-1A receptor in the forebrain. These data provide genetic evidence that sex steroid hormones are dispensable for the viability, but exert an anxiolytic effect via serotonin-1A receptor in males.

Research Products

• [Journal Article] Noncanonical Wnt signaling mediates androgen-dependent tumor growth in a mouse model of prostate cancer. (2011)
  • Author(s): Takahashi S.
  • Journal Title: Proc Natl Acad Sci U S A Volume: 108 Pages: 4938-4943
  • Peer Reviewed
• [Journal Article] Essential roles of androgen signaling in wolffian duct stabilization and epididymal cell differentiation. (2011)
  • Author(s): Murashima A.
  • Journal Title: Endocrinology Volume: 152 Pages: 1640-1651
  • Peer Reviewed
• [Journal Article] TSPY represses the activity of the androgen receptor in androgen-dependent testicular germ cell tumors. (2010)
  • Author(s): Akimoto C.
  • Journal Title: Proc Natl Acad Sci U S A Volume: 107 Pages: 19891-19896
  • Peer Reviewed
• [Journal Article] DNA demethylation in hormone-induced transcriptional derepression. (2009)
  • Author(s): Kim M., Kondo T., Takada I., Youn M., Yamamoto Y., Takahashi S., Matsumoto T., (他13名).
  • Journal Title: Nature 461 Pages: 1007-1012
  • Peer Reviewed
• [Journal Article] Distinct function of 2 chromatin remodeling complexes that share a common subunit, Williams syndrome transcription factor (WSTF). (2009)
  • Author(s): Yoshimura K., Kitagawa H., Fujiki R., Tanabe M., Takezawa S., Takada I., Yamaoka I., Yonezawa M., Kondo T., Furutani Y., Yagi H., Yoshinaga S., Masuda T., Fukuda T., Yamamoto Y., Ebihara K., Li DY., Matsuoka R., Takeuchi JK., Matsumoto T., Kato S.
  • Journal Title: Proc Natl Acad Sci USA 106 Pages: 9280-9285
  • Peer Reviewed
• [Journal Article] Co-activation of ERb by a gonadotropin-induced cofactor GIOT-4. (2009)
  • Author(s): Kouzu-Fujita M., Mezaki Y., Sawatsubashi S., Matsumoto, T., (他5名).
  • Journal Title: Mol Cell Biol 29 Pages: 83-92
  • Peer Reviewed
• [Journal Article] DNA demethylation in hormone-induced transcriptional deprepression (2009)
  • Author(s): Kim M.
  • Journal Title: Nature 461 Pages: 1007-1012
  • Peer Reviewed
• [Journal Article] Distinct function of 2 chromatin remodeling complexes that share a common subunit, Williams syndrome transcription factor(WSTF) (2009)
  • Author(s): Yoshimura K.
  • Journal Title: Proc Natl Acad Sci USA 106 Pages: 9280-9285
  • Peer Reviewed
• [Journal Article] Coactivation of estrogen receptor beta by gonadotropin-induced cofact or GIOT-4. (2009)
  • Author(s): Kouzu-Fujita M
  • Journal Title: Mol Cell Biol 29 Pages: 83-92
  • Peer Reviewed
• [Journal Article] TSPY represses the activity of the androgen receptor in androgen-dependent testicular germ cell tumors.
  • Author(s): Akimoto C, et al., (他13名 Matsumoto T.13番目)
  • Journal Title: Proc Natl Acad Sci USA in press
  • Peer Reviewed
• [Presentation] 性ステロイド受容体トリプル欠損マウスを用いた生体内機能解析 (2010)
  • Author(s): 松本高広
  • Organizer: 第33回日本分子生物学会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-07
• [Presentation] Receptors Triple Knockout Mice to Evaluate Sex Steroid Hormones Actions. (2010)
  • Author(s): Matsumoto T.Androgen, Estrogen
  • Organizer: 14th International Congress of Endocrinology
  • Place of Presentation: 京都
  • Year and Date: 2010-03-28
• [Presentation] Androgen and Estrogen Receptors Triple Knockout Mice to Evaluate Sex Steroids Hormones Actions (2010)
  • Author(s): Matsumoto T.
  • Organizer: 14^<th> International Congress of Endocrinology
  • Place of Presentation: Kyoto
  • Year and Date: 2010-03-28
• [Book] 現代栄養学を理解するための分子生物学 (2010)
  • Author(s): 松本高広
  • Publisher: 入門光生館
• [Book] 現代栄養学を理解するための分子生物学入門 (2010)
  • Author(s): 松本高広
  • Publisher: 光生館
• [Remarks] ホームページ等