Analysis of the molecular mechanisms of constitutive activation of NFκB and its target genes involved in tumorigenesis in the malignant breast cancer.

• Project/Area Number: 21790310
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pathological medical chemistry
• Research Institution: The University of Tokyo
• Principal Investigator: YAMAGUCHI Noritaka The University of Tokyo, 医科学研究所, 助教 (80399469)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: シグナル伝達

Research Abstract

The transcription factor NFκB is constitutively activated in malignant breast cancer. In the present study, we analyzed its target genes and molecular mechanisms leading to its activation. As a result, we found that NFκB induces expression of genes involved in cell proliferation and invasion/metastasis in the breast cancer. We also found that expression of NIK, one of NFκB activators, is up-regulated in the cancer. I expect that these results support development of novel therapies against the breast cancer.

Research Products

• [Journal Article] Epigenetic alteration of the NF-κB-inducing kinase (NIK) gene is involved in enhanced NIK expression in basal-like breast cancer. (2010)
  • Author(s): Yamamoto M, Ito T, Shimizu T, Ishida T, Semba K, Watanabe S, Yamaguchi N, Inoue J.
  • Journal Title: Cancer Sci. 101 Pages: 2391-2397
  • NAID: 10027833532
  • Peer Reviewed
• [Journal Article] Epigenetic alteration of the NF-κB-inducing kinase (NIK) gene is involved in enhanced NIK expression in basal-like breast cancer. (2010)
  • Author(s): Yamamoto M, et al.
  • Journal Title: Caner Science Volume: 101 Pages: 2391-2397
  • Peer Reviewed
• [Journal Article] NIK is involved in constitutive activation of the alternative NF-κB pathway and proliferation of pancreatic cancer cells. (2009)
  • Author(s): Nishina T, Yamaguchi N, Gohda J, Semba K, Inoue J.
  • Journal Title: Biochem Biophys Res Commun. 388 Pages: 96-101
  • Peer Reviewed
• [Presentation] NIK-dependent constitutive activation of NF-κB is involved in the proliferation of basal-like subtype breast cancer cell lines. (2011)
  • Author(s): Yamaguchi N, Kureha-Ito T, Yamamoto M, Inoue J
  • Place of Presentation: Keystone Symposia, Keystone USA
• [Presentation] NIK-dependent constitutive activation of NF-κB is involved in the proliferation of basal-like subtype breast cancer cell lines (2011)
  • Author(s): Yamaguchi N
  • Organizer: Keystone Symposia
  • Place of Presentation: Keystone, USA
• [Presentation] 乳癌源細胞における転写因子NF-κB活性化の役割 (2010)
  • Author(s): 山本瑞生、山口憲孝、渡邊慎哉、仙波憲太郎、井上純一郎
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-24
• [Presentation] 乳癌における新規NF-κB標的遺伝子の探索 (2010)
  • Author(s): 伊藤拓、山口憲孝、渡邊慎哉、仙波憲太郎、井上純一郎
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-22
• [Presentation] Constitutive activation of NFκB in human cancer cell lines. (2009)
  • Author(s): 山口憲孝、井上純一郎
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-09
• [Presentation] Constitutive activation of NFkB in human cancer cell lines. (2009)
  • Author(s): 山口憲孝
  • Organizer: 第32回 分子生物学会年会
  • Place of Presentation: 横浜・パシフィコ横浜
  • Year and Date: 2009-12-09
• [Presentation] 膵臓がん細胞においてNuclear factor-κB inducing kinase (NIK)はNF-κBの恒常的活性化と細胞増殖に寄与する (2009)
  • Author(s): 仁科隆史、山口憲孝、仙波憲太郎、井上純一郎
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-02
• [Presentation] 乳癌における新規NF-κB標的遺伝子の探索 (2009)
  • Author(s): 伊藤拓、山口憲孝、仙波憲太郎、井上純一郎
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-01
• [Presentation] Basalタイプ乳癌細胞におけるNF-κB inducing kinase (NIK)発現亢進のメカニズム解析 (2009)
  • Author(s): 山本瑞生、山口憲孝、仙波憲太郎、井上純一郎
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-01
• [Remarks] ホームページ等
  • URL: http://www.ims.u-tokyo.ac.jp/BunshiHatsugan/index.html
• [Remarks]
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• [Remarks]
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