Regulation of tissue regeneration, disease and oncogenesis through the natural isoform of the Met/HGF receptor
| Project/Area Number |
21790312
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
NAKAMURA Takahiro Kanazawa University, がん研究所, 助教 (70414018)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | HGF / Met / 組織再生 / シグナル伝達 / 細胞増殖因子 |
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| Research Abstract |
To address the function of the natural isoform of the Met/HGF receptor during tissue regeneration, disease and oncogenesis, I prepared the MDCK cells that stably express the ΔJM-Met or WT-Met gene and ΔJM-Met knockin mice. As a result, I could not find the any difference between ΔJM-Met and WT-Met expressed MDCK cells in the ability of motility and morphogenesis. Δ JM-Met knockin mice were resulted in embryonic lethal.
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Report
(3 results)
Research Products
(23 results)
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[Journal Article] Inhibition of Met/HGF receptor and angiogenesis by NK4 leads to suppression of tumor growth and migration in malignant pleural mesothelioma.2010
Author(s)
Suzuki, Y., Sakai, K., Ueki, J., Xu, Q., Nakamura, T., Shimada, H., Nakamura, T., Matsumoto, K.
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Journal Title
Int.J.Cancer 127
Pages: 1948-1957
Related Report
Peer Reviewed
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[Journal Article] T.Systemic NK4 gene therapy inhibits tumor growth and metastasis of melanoma and lung carcinoma in syngeneic mouse tumor models.2009
Author(s)
Kishi, Y., Kuba, K., Nakamura, T., Wen, J., Suzuki, Y., Mizuno, S, Nukiwa, T., Matsumoto, K, Nakamura
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Journal Title
Cancer Sci. 100
Pages: 1351-1358
Related Report
Peer Reviewed
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[Journal Article] T.Diseasedependent reciprocal phosphorylation of serine and tyrosine residues of c-Met/HGF receptor contributes disease retardation of a transgenic mouse model of ALS.2009
Author(s)
Kadoyama, K., Funakoshi, H., Ohya- Shimada, W., Nakamura, T., Matsumoto, K., Matsuyama, S., Nakamura
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Journal Title
Neurosci.Res. 65
Pages: 194-200
Related Report
Peer Reviewed
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