Targeting endothelial lipase as a novel therapeutic strategy for the treatment of atherosclerosis
| Project/Area Number |
21790314
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Pathological medical chemistry
|
|---|
| Research Institution | University of Yamanashi |
|---|
Principal Investigator |
KOIKE Tomonari University of Yamanashi, 大学院・医学工学総合研究部, 助教 (40432158)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 分子病態学 / 動脈硬化 / 内皮リパーゼ / in situ hybridization / 脂質異常症 / HDL / アンチセンス / トランスジェニックウサギ |
|---|
| Research Abstract |
To establish a novel strategy for raising plasma HDL-cholesterol levels, we analyzed the functions of endothelial lipase (EL), a newly-identified HDL phospholipase, using rabbit models. We found that EL expression was increased in rabbits with low HDL-cholesterol levels. Inhibition of EL expression using EL specific antisense led to increased plasma HDL-cholesterol levels. These results indicate the therapeutic inhibition of EL activity may become a new mean to elevate plasma HDL levels.
|
Report
(3 results)
Research Products
(31 results)
-
[Journal Article] Human C-reactive protein enhances thrombus formation after neointimal balloon injury in transgenic rabbits.2011
Author(s)
Matsuda S, Yamashita A, Sato Y, Kitajima S, Koike T, Sugita C, Moriguchi-Goto S, Hatakeyama K, Takahashi M, Koshimoto C, Matsuura Y, Iwakiri T, Chen Y.E, Fan J, Asada Y
-
Journal Title
J Thromb Haemost 9
Pages: 201-208
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] Human C-reactive protein does not promote atherosclerosis in transgenic rabbits.2009
Author(s)
Koike T, Kitajima S, Yu Y, Nishijima K, Zhang J, Ozaki Y, Morimoto M, Watanabe T, Bhakdi S, Asada Y, Chen Y.E, Fan, J
-
Journal Title
Circulation 120
Pages: 2088-2094
Related Report
Peer Reviewed
-
[Journal Article] Expression of human apoAII in transgenic rabbits leads to dyslipidemia: a new model for combined hyperlipidemia2009
Author(s)
Koike T, Kitajima S, Yu Y, Li Y, Nishijima K, Liu E, Sun H, Waqar A.B., Shibata N, Inoue T, Wang Y, Zhang B, Kobayashi J, Morimoto M, Saku K, Watanabe T, Fan J
-
Journal Title
Arterioscler Thromb Vasc Biol 29
Pages: 2047-2053
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
[Presentation] Expression of Human ApoAII in Transgenic Rabbits Leads to Dyslipidemia -A New Model for Combined Hyperlipidemia.2010
Author(s)
Koike T, Kitajima S, Yu Y, Nishijima K, Waqar AB, Inoue T, Wang Y, Bo Z, Kobayashi, J, Morimoto M, Saku K, Watanabe T, Fan J
Organizer
第42回日本動脈硬化学会総会・学術集会
Place of Presentation
岐阜市
Related Report
-
-
-
-
-
-
[Presentation] Transgenic rabbits expressing Human C-reactive protein.2009
Author(s)
Koike T, Kitajima S, Yu Y, Nishijima K, Zhang J, Ozaki Y, Morimoto M, Watanabe T, Asada Y, Chen E, Fan J
Organizer
第41回日本動脈硬化学会総会・学術集会
Place of Presentation
下関市
Related Report
-
-
-
-
-
-
-
-
-
