| Project/Area Number |
21790314
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | University of Yamanashi |
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Principal Investigator |
KOIKE Tomonari University of Yamanashi, 大学院・医学工学総合研究部, 助教 (40432158)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 分子病態学 / 動脈硬化 / 内皮リパーゼ / in situ hybridization / 脂質異常症 / HDL / アンチセンス / トランスジェニックウサギ |
|---|
| Research Abstract |
To establish a novel strategy for raising plasma HDL-cholesterol levels, we analyzed the functions of endothelial lipase (EL), a newly-identified HDL phospholipase, using rabbit models. We found that EL expression was increased in rabbits with low HDL-cholesterol levels. Inhibition of EL expression using EL specific antisense led to increased plasma HDL-cholesterol levels. These results indicate the therapeutic inhibition of EL activity may become a new mean to elevate plasma HDL levels.
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