| Project/Area Number |
21790316
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Gifu Pharmaceutical University (2010-2011)
Mie University (2009) |
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Principal Investigator |
AOKI Shinya 岐阜薬科大学, 薬学部, 助教 (10508758)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | スフィンゴシン1-リン酸 / 組織因子 / 炎症生因子 / 動脈硬化 / 血栓症 / 血栓 / 血管内皮細胞 / 赤血球 / 血小板 / LDL / HDL / アルブミン / トロンボキサンA_2 / 動脈硬化症 / 血液凝固反応 / 血栓形成 / 炎症 |
|---|
| Research Abstract |
Sphingosine 1-phosphate(Sph-1-P), abundantly stored in platelets, is released by the platelets' activation. However, the role of released Sph-1-P from activated platelets is remained unclear. In the present study, it was revealed that, in vascular endothelial cells, 1) the supernatant of the activated platelets(Plt-sup) enhanced TNF-a-induced expression of tissue factor(TF), an initiator of coagulation system, that was stimulated by Sph-1-P into the Plt-sup, 2) that Sph-1-P could enhance the expression of TF induced by inflammatory mediators, and 3) that Sph-1-P promoted TF expression by the induction of the transcriptional factors such as Egr-1, NF-kB and AP-1 through MAPK cascade. These results suggest that Sph-1-P would closely be involved in the exacerbation of arteriosclerosis and thrombosis disease.
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