| Project/Area Number |
21790318
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kobe University |
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Principal Investigator |
KANAGAWA Motoi Kobe University, 大学院・医学研究科, 助教 (00448044)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | フクチン / ジストログリカン / 福山型筋ジストロフィー / 糖鎖異常 / 筋形成維持 / 筋形成・維持 |
|---|
| Research Abstract |
Fukuyama-type muscular dystrophy, which is caused by mutations in the fukutin gene, is a severe congenital form of muscular dystrophy. Pathogenesis of this disorder is poorly understood and currently no effective treatment is available. In this study, we generated conditional knock-out mice that lack fukutin selectively in the skeletal muscle. These mice showed pathology similar to Fukuyama-type muscular dystrophy, and thus would be a useful model for understanding molecular pathogenesis and establishing therapeutic strategy such as gene therapy.
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