Epigenetic approach to the elucidation of the molecular pathogenesis of autoimmune disease
| Project/Area Number |
21790321
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
YANO Masashi The University of Tokushima, 疾患酵素学研究センター, 技術員 (10531858)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 自己寛容 / 胸腺 / AIRE |
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| Research Abstract |
Autoimmune disease is still intractable with unknown mechanisms for the disease. Because AIRE gene has been demonstrated to regulate a large battery of tissue-restricted antigen (TRA) genes from medullary thymic epithelial cells (mTECs), there is a good hope that elucidating the roles of AIRE would reveal the molecular pathogenesis of autoimmune disease. In this study, we have tried to understand the molecular mechanisms underlying the expression of TRA genes regulated by AIRE from mTECs from an epigenetic viewpoint. Especially, we have focused on the function of AIRE in ES cells, since we have discovered its expression in this unique cell-type.
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Report
(3 results)
Research Products
(9 results)
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[Journal Article] Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma.2011
Author(s)
Mouri Y, Yano M, Shinzawa M, Shimo Y, Hirota F, Nishikawa Y, Nii T, Kiyonari H, Abe T, Uehara H, Izumi K, Tamada K, Chen L, Penninger JM, Inoue J, Akiyama T, Matsumoto M.
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Journal Title
J.Immunol. 186
Pages: 5047-5057
Related Report
Peer Reviewed
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