Analysis of a membrane bound transcription factor OASIS in osteogenesis
| Project/Area Number |
21790323
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | University of Miyazaki |
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Principal Investigator |
MURAKAMI Tomohiko University of Miyazaki, 医学部, 助教 (50510723)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 小胞体 / 骨形成 / コラーゲン / 分泌 / 成長 / I型コラーゲン |
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| Research Abstract |
To assess the role of OASIS in vivo, we generated OASIS deficient mice. The mice exhibited osteopenia and growth retardation. Histological, and molecular and cellular biological analyses revealed that OASIS is involved in bone formation through transcription of type I collagen and secretion of bone matrix proteins. In contrast, the growth retardation in OASIS deficient mice were not improved by OASIS introduction in osteoblasts, indicating that the growth retardation is caused by the decrease in growth hormone and IGF-1 levels in OASIS deficient mice.
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Report
(3 results)
Research Products
(24 results)
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[Journal Article] Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation.2009
Author(s)
Murakami T, Saito A, Hino S-I, Kondo S, Kanemoto S, Chihara K, Sekiya H, Tsumagari K, Ochiai K, Yoshinaga K, Saitoh M, Nishimura R, Yoneda T, Kou I, Furuichi T, Ikegawa S, Ikawa M, Okabe M, Wanaka A, Imaizumi K.
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Journal Title
Nature Cell Biology 11(10)
Pages: 1205-1211
Related Report
Peer Reviewed
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[Journal Article] Regulation of endoplasmic reticulum stress response by a BBF2H7-mediated Sec23a pathway is essential for chondrogenesis.2009
Author(s)
Saito A, Hino S-I, Murakami T, Kanemoto S, Kondo S, Saitoh M, Nishimura R, Yoneda T, Furuichi T, Ikegawa S, Ikawa M, Okabe M, Imaizumi K.
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Journal Title
Nature Cell Biology 11(10)
Pages: 1197-1204
Related Report
Peer Reviewed
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