| Project/Area Number |
21790329
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
AOKI Katsuhiko Jikei University School of Medicine, 医学部, 助教 (80328278)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 癌 |
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| Research Abstract |
The purpose of this study is to evaluate the relationship between the function of EMMPRIN-MCT complex and the invasiveness and metastasis of tumor cells. Main findings were as follows : (1) 3-Bromopyruvate, a lactate analog, was transported into PC-3 cells actively through the EMMPRIN-MCT1 complex. (2) Improvements in the sensitivity of co-immunoprecipitation method revealed that the existence of novel endogenous interactors for EMMPRIN such as CA9, in addition to already identified MCT1, MCT4, MMP1 and PDLIM7.
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