| Project/Area Number |
21790330
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
|---|
| Research Field |
Pathological medical chemistry
|
|---|
| Research Institution | Tokyo Women's Medical University |
|---|
Principal Investigator |
TOMITA Takeshi Tokyo Women's Medical University, 医学部, 助教 (20302242)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 分子腫瘍学 / 血清アミロイドA3 / 腫瘍転移 / クララ細胞 |
|---|
| Research Abstract |
In tumor metastasis, primary tumor secretes cytokines to stimulate remote organs to induce a pre-metastatic phase, which facilitates tumor cells migration. This project revealed that Clara cell, located only in terminal bronchioles, functions as a control tower of serum amyloid A3 cascade, a culprit of the pre-metastatic phase formation, by using animal model, organ culture, and cell culture techniques.
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