Molecular mechanism of serum amyloid signaling in lung metastasis

• Project/Area Number: 21790330
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pathological medical chemistry
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: TOMITA Takeshi Tokyo Women's Medical University, 医学部, 助教 (20302242)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 分子腫瘍学 / 血清アミロイドA3 / 腫瘍転移 / クララ細胞

Research Abstract

In tumor metastasis, primary tumor secretes cytokines to stimulate remote organs to induce a pre-metastatic phase, which facilitates tumor cells migration. This project revealed that Clara cell, located only in terminal bronchioles, functions as a control tower of serum amyloid A3 cascade, a culprit of the pre-metastatic phase formation, by using animal model, organ culture, and cell culture techniques.

Research Products

• [Journal Article] Imbalance of Clara cell-mediated homeostatic inflammation is involved in lung metastasis (2011)
  • Author(s): Tomita T., Sakurai Y., Ishibashi S., Maru Y.
  • Journal Title: Oncogene in press
  • Peer Reviewed
• [Journal Article] FOXA1 plays a role in regulating Secretoglobin 1a1 expression in the absence of CAATT/Enhancer Binding Protein activities in lung in vivo (2011)
  • Author(s): Kido T., Tomita T., Okamoto M., Cai Y., Matsumoto Y., Vinson C., Maru Y., Kimura S.
  • Journal Title: Am.J.Physiol.Lung Cell Mol.Physiol. in press
  • Peer Reviewed
• [Journal Article] Imbalance of Clara cell-mediated homeostatic inflammation is involved in lung metastasis (2011)
  • Author(s): Tomita T., Sakurai Y., Ishibashi S., Maru Y.
  • Journal Title: Oncogene Volume: (in press)
  • Peer Reviewed
• [Journal Article] FOXA1 plays a role in regulating Secretoglobin 1a1 expression in the absence of CAATT/Enhancer Binding Protein activities in lung in vivo (2011)
  • Author(s): Kido T., Tomita T., Okamoto M., Cai Y., Matsumoto Y., Vinson C., Maru Y., Kimura S.
  • Journal Title: Am.J.Physiol Lung Cell Mol.Physiol. Volume: (in press)
  • Peer Reviewed
• [Presentation] クララ細胞によるS100A8-SAA3-TLR4を介した肺特異的転移の機構 (2010)
  • Author(s): 富田毅、丸義朗
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-23
• [Presentation] Clara cell regulates organotropism in pulmonary metastasis via S100A8-serum amyloid A3-TLR4 signaling (2010)
  • Author(s): Tomita T., Maru Y.
  • Organizer: 69^<th> Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-09-22
• [Presentation] Organ specific resident cells with TLR4 determine organotropism in metastasis (2010)
  • Author(s): Tomita T., Maru Y.
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: 神戸
  • Year and Date: 2010-08-23
• [Presentation] Organ specific resident cells with TLR4 determine organotropism in metastasis (2010)
  • Author(s): Tomita T., Sakurai Y., Maru Y.
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2010-08-23
• [Presentation] Organ specific resident cells determine organotropism in metastasis (2010)
  • Author(s): Tomita T., Maru Y.
  • Organizer: 8th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association
  • Place of Presentation: ハワイ
  • Year and Date: 2010-02-08
• [Presentation] 肺特異的転移におけるクララ細胞の役割 (2009)
  • Author(s): 富田毅、丸義朗
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-03