Molecular pathology of the mechanism of the invasion and metastasis of cholangiocarcinoma-From the aspects of epithelial-mesenchymal transition

• Project/Area Number: 21790346
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Human pathology
• Research Institution: Kanazawa University
• Principal Investigator: SATO Yasunori Kanazawa University, 医学系, 講師 (30324073)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 人体病理学 / 肝臓 / 胆管癌 / 上皮・間葉変換

Research Abstract

Epithelial-mesenchymal transition (EMT) is an important mechanism behind the initiation of cancer invasion and metastasis. This study was performed to clarify the involvement of EMT in the progression of cholangiocarcinoma. Studies using cholangiocarcinoma cell lines and surgically resected specimens of cholangiocarcinoma demonstrated that EMT induced by transforming growth factor-β1/Snail activation was closely associated with the aggressive growth of cholangiocarcinoma, resulting in a poor prognosis.

Research Products

• [Journal Article] 胆管硬化とEMT (2011)
  • Author(s): 佐藤保則、原田憲一、中沼安二
  • Journal Title: 肝胆膵 62 Pages: 743-750
• [Journal Article] Epitheli al-mesenchymal transition induced by transforming growth factor-・1/Snai l activationaggravates invasive grow th of cholangiocarcinoma. (2010)
  • Author(s): Sato Y, Harada K, Itatsu K, Ikeda H, Kakuda Y, Shimomura S, Ren XS, Yone da N, Sasaki M, Nakanuma Y.
  • Journal Title: Am J Pathol 177 Pages: 141-152
  • Peer Reviewed
• [Journal Article] Epithelial-mesenchymal transition induced by transforming growth factor-β1/Snail activation aggravates invasive growth of cholangiocarcinoma. (2010)
  • Author(s): Sato.Y., et al
  • Journal Title: Am J Pathol Volume: 177 Pages: 141-152
  • Peer Reviewed
• [Journal Article] Epithelial-mesenchymal transition induced by transforming growth factor-β1/Snail activation aggravates invasive growth of cholangiocarcinoma (2010)
  • Author(s): Sato.Y., et al
  • Journal Title: Am J Pathol (In press)
  • Peer Reviewed
• [Presentation] Epithelial-mesenchymal transition induced by transforming growth factor-・1 aggravates invasive growth of cholangiocarcinoma. (2009)
  • Author(s): Sato Y, Yoneda N, Ren XS, Sasaki M, Harada K, Nakanuma Y.
  • Organizer: 60^th AASLD
  • Place of Presentation: John B.Hynes Veterans Memorial Convention Center (USA)
  • Year and Date: 2009-11-02
• [Presentation] Epithelial-mesenchymal transition induced by transforming growth factor-β1 aggravates invasive growth of cholangiocarcinoma (2009)
  • Author(s): Sato. Y., et al
  • Organizer: 60^<th>AASLD
  • Place of Presentation: John B.Hynes Veterans Memorial Convention Center (USA)
  • Year and Date: 2009-11-02
• [Presentation] 胆管癌の浸潤・転移機構における上皮-間葉変換(EMT)の関与 (2009)
  • Author(s): 佐藤保則、下村修治、角田優子、池田博子、佐々木素子、原田憲一、中沼安二
  • Organizer: 第45回日本肝臓学会総会
  • Place of Presentation: 神戸ポートピアホテル(兵庫県)
  • Year and Date: 2009-06-05
• [Presentation] 胆管癌の浸潤・転移における上皮・問葉変換機構(EMT)の関与 (2009)
  • Author(s): 佐藤保則, ほか
  • Organizer: 第45回日木肝臓学会総会
  • Place of Presentation: 神戸ポートピアホテル(兵庵県)
  • Year and Date: 2009-06-05
• [Presentation] 胆管癌の浸潤・転移における上皮・間葉変換機構(EMT)の関与 (2009)
  • Author(s): 佐藤保則、下村修治、角田優子、池田博子、佐々木素子、原田憲一、中沼安二
  • Organizer: 第98回日本病理学会総会
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2009-05-02
• [Presentation] 胆管癌の浸潤・転移における上皮・問葉変換機構(EMT)の関与 (2009)
  • Author(s): 佐藤保則, ほか
  • Organizer: 第98剣旧本病理学会総会
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2009-05-02