| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Research Abstract |
Overexpression of adenosine receptors have recently been identified in several human cancers. The purpose of this study is to examine expression of adenosine receptor and its molecular analysis in thyroid tumors. Compared with normal thyroid tissues and benign tumors(follicular adenomas), expression of adenosine receptor 1(ADRA1) was up-regulated in thyroid carcinomas. Furthermore, this observation increased tumor cell growth and invasion in vitro. These result may suggest the adenosinergic system as a potential pharmacological target in thyroid cancer therapeutics
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