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Analysis of molecular alterations in IgG4-related sclerosing disease

Research Project

Project/Area Number 21790349
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Human pathology
Research InstitutionShinshu University

Principal Investigator

UEHARA Takeshi  Shinshu University, 医学部, 講師 (80402121)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
KeywordsIgG4関連硬化性疾患 / 自己免疫性膵炎 / 胃炎
Research Abstract

This study show diagnostic approach of IgG4-related sclerosing disease and cause investigation of IgG4-related sclerosing disease. Immunohistochemical staining was performed to IgG subclasses in the gastric biopsy got from IgG4-related sclerosing disease patient. The gastric inflammation consisted with pancreatic inflammation in IgG4-related sclerosing disease patient. The gastric biopsy is more useful than the pancreatic biopsy, so the gastric biopsy is diagnostic. Although, normal pancreatic epithelial cell and stroma cell were stimulated with human serum containing IgG subclasses, they didn't show any change.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (14 results)

All 2011 2010 2009

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (6 results)

  • [Journal Article] IgG4-related pleural diseasediagnosed by a re-evaluation ofchronic bilateral pleuritis in apatient who experienced occasionalacute left bacterial pleuritis.2011

    • Author(s)
      Yamamoto H, Suzuki T, Yasuo M,Kobayashi O, Tsushima K, Ito M, Urushihata K, YAMAZAKI Y, Hanaoka M, Koizumi T, UEHARA T(他4 名、11 番目)
    • Journal Title

      InternMed 50

      Pages: 893-897

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] IgG4-related chronicrhinosinusitis: a new clinical entityof nasal disease.2010

    • Author(s)
      Moteki H, Yasuo M, Hamano H, UEHARA T(他1名、4番目)
    • Journal Title

      Acta Otolaryngol 131

      Pages: 518-26

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chronicgastritis in the setting of autoimmunepancreatitis.2010

    • Author(s)
      UEHARA T(他12名、1番目)
    • Journal Title

      Am J Surg Pathol 34

      Pages: 1241-1249

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 病因と病態(特集膵炎-診断と治療の進歩)-(自己免疫性膵炎).2010

    • Author(s)
      川茂幸, 浜野英明, 上原剛
    • Journal Title

      日本内科学会雑誌 99

      Pages: 76-81

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chronic gastritis in the setting of autoimmune pancreatitis2010

    • Author(s)
      Uehara T
    • Journal Title

      American Journal of Surgical Pathology

      Volume: 34 Pages: 1241-1249

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pulmonaryinvolvement of autoimmunepancreatitis.2009

    • Author(s)
      Tsushima K, Tanabe T, Yamamoto H, Koizumi T, Kawa S, Hamano H, Honda T, UEHARA T(他2名、8番目)
    • Journal Title

      Eur J Clin Invest 39

      Pages: 714-722

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Centralairway stenosis in a patient withautoimmune pancreatitis.2009

    • Author(s)
      Ito M, Yasuo M, Yamamoto H, Tsushima K, Tanabe T, Yokoyama T, Hamano H, KAWA S UEHARA T(他3名、9番目)
    • Journal Title

      Eur Respir J 33

      Pages: 680-683

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 【自己免疫性膵炎の最前線】自己免疫性膵炎の診断2009

    • Author(s)
      藤永康成, 杉山由紀子, 角谷眞澄, 上田和彦, 黒住昌弘, 山崎幸恵, 浜野英明, 川茂幸, 上原剛(他1名、8番目)
    • Journal Title

      膵癌との鑑別を中心にCT・MRI・PET肝胆膵画像 11

      Pages: 631-638

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] IgG4関連疾患における鼻副鼻腔病変の検討2011

    • Author(s)
      茂木英明、工穣、宇佐美真一、安尾将法、濱野英明、上原剛(他1名、6番目)
    • Organizer
      第5回IgG4研究会
    • Place of Presentation
      札幌
    • Year and Date
      2011-03-12
    • Related Report
      2010 Final Research Report
  • [Presentation] 肥厚性硬膜炎の経過中に胸椎前面を中心とする背側胸膜の炎症性肥厚を認めmultifocal fibrosclerosisと診断された1例2010

    • Author(s)
      大學愛子、宮崎大吾、福島和広、下島恭弘、小林宣隆、上原剛(他2名、6番目)
    • Organizer
      第127回日本内科学会信越地方会
    • Place of Presentation
      松本
    • Year and Date
      2010-11-13
    • Related Report
      2010 Final Research Report
  • [Presentation] IgG4関連硬化性疾患の診断2010

    • Author(s)
      上原剛
    • Organizer
      第57回日本臨床検査医学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-10
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 細胞診検体を用いた自己免疫性膵炎(AIP)の検討2009

    • Author(s)
      上原弥生、小林幸弘,堀川美栄子、上原剛(4番目)
    • Organizer
      第48回日本臨床細胞学会秋期大会
    • Place of Presentation
      福岡
    • Year and Date
      2009-10-30
    • Related Report
      2010 Final Research Report
  • [Presentation] IgG4 関連硬化性疾患-消化器病変を中心に-2009

    • Author(s)
      上原剛
    • Organizer
      第21回日本消化器病学会甲信越支部会
    • Place of Presentation
      松本
    • Year and Date
      2009-06-13
    • Related Report
      2010 Final Research Report
  • [Presentation] IgG4関連硬化性疾患-消化器病変を中心に-2009

    • Author(s)
      上原剛
    • Organizer
      日本消化器病学会
    • Place of Presentation
      松本
    • Year and Date
      2009-06-13
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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