| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
To identify cancer stem cells in malignant lymphoma, it is necessary that cells sorted as a candidate of cancer stem cells were injected into NOD/SCID mice. In Hodgkin lymphoma cell lines, concentration of intracellular reactive oxygen species was at a low level in a portion of single-nucleated small sized (S) cells. When cultured in methylcellulose or inoculated into NOD/SCID mice, the colony number and tumor size were larger in S than in multinucleated large-sized cells.
These findings suggest that small-sized cells might play an important role in tumorigenesis of Hodgkin lymphoma.
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