| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
Alveolar soft part sarcoma contains specific chimeric oncogene ASPL-TFE3, which has been thought to play a crucial role in the onset and progression of alveolar soft part sarcoma. In this study, the candidate genes whose expression is regulated by ASPL-TFE3 were investigated by using DNA microarray analysis. In response to ASPL-TFE3 expression, we found that 739 genes were up-regulated at least 2-fold higher than in untreated cells, and 169 genes were down-regulated at least 0. 5-fold lower than in untreated cells. Transcriptional targets of ASPL-TFE3 include metabolic genes, cell proliferation genes, apoptotic genes and signal transduction genes. These results suggest that ASPL-TFE3 contribute to oncogenesis and pathology of alveolar soft part sarcoma by inducing the aberrant expression of transcriptional target genes implicated in cell proliferation and signal transduction.
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