| Project/Area Number |
21790353
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Human pathology
|
|---|
| Research Institution | Hiroshima University |
|---|
Principal Investigator |
SENTANI Kazuhiro Hiroshima University, 大学院・医歯薬学総合研究科, 助教 (30508164)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 診断病理学 / 胃癌 / connexin 30 / 腫瘍進展 / 大腸癌 / claudin-18 / CDX2 / 予後 / lamininγ2 |
|---|
| Research Abstract |
Several discrete steps can be discerned in the biological cascades of tumor progression, and several molecules involved in their processes had been reported in gastric cancer (GC). In the present study, we searched for novel genes associated with tumor progression, based on the data of comprehensive gene expression methods. MMP7 and lamininγ2 were associated with tumor progression in GC. In contrast, connexin 30 expression reduced during tumor progression, and is a novel differentiation marker mediating the biological behavior of intestinal phenotype GC. Furthermore, claudin-18 expression correlates with poor survival in patients with CRC and is associated with the gastric phenotype.
|
