The investigation of carcinogenesis for intrahepatic cholangiocarcinoma arising from chronic hepatitis or liver cirrhosis

• Project/Area Number: 21790355
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Human pathology
• Research Institution: Kyushu University
• Principal Investigator: AISHIMA Shinichi Kyushu University, 医学研究院, 准教授 (70346774)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 消化器 / 胆管癌 / 肝硬変 / 肝炎 / 胆管前駆病変 / 肝内胆管癌 / S100P / Ezrin / RAGE / 胆管癌前駆病変 / ウイルス性肝炎 / 酸化ストレス

Research Abstract

P62-positive hyaline inclusion was observed in intrahepatic cholangiocarcinoma arising from chronic liver disease. The histologic characters of biliary neoplasia arising from liver cirrhosis is similar with that arising from chronic biliary disease, in the points of gastric mucin (MUC5AC), p16, and p21 proteins.

Research Products

• [Journal Article] Different roles of S100P Overexpression in Intrahepatic Cholangiocarcinoma: Carcinogenesis of Perihilar Type and Aggressive Behavior of Peripheral Type. (2011)
  • Author(s): Aishima S, Fujita N, Mano Y, Kubo Y, Tanaka Y, Taketomi A, Shirabe K, Maehara Y, Oda Y.
  • Journal Title: Am J Surg Pathol. 35 Pages: 590-598
  • NAID: 120004951589
  • Peer Reviewed
• [Journal Article] Different roles of S100P Overexpression in Intrahepatic Cholangiocarcinoma : Carcinogenesis of Perihilar Type and Aggressive Behavior of Peripheral Type. (2011)
  • Author(s): Aishima S, et al.
  • Journal Title: American Journal of Surgical Pathol Volume: 35 Pages: 590-598
  • NAID: 120004951589
  • Peer Reviewed
• [Journal Article] A history of acute pancreatitis in intraductal papillary mucinous neoplasms of the pancreas is a potential predictive factor for malignant papillary subtype. (2010)
  • Author(s): Tsutsumi K, Ohtsuka T, Oda Y, Sadakari Y, Mori Y, Aishima S, Takahata S, Nakamura M, Mizumoto K, Tanaka M.
  • Journal Title: Pancreatology. 10 Pages: 707-712
  • Peer Reviewed
• [Journal Article] Invasive carcinoma derived from the nonintestinal type intraductal papillary mucinous neoplasm of the pancreas has a poorer prognosis than that derived from the intestinal type. (2010)
  • Author(s): Sadakari Y, Ohuchida K, Nakata K, Ohtsuka T, Aishima S, Takahata S, Nakamura M, Mizumoto K, Tanaka M
  • Journal Title: Surgery 147 Pages: 812-817
  • Peer Reviewed
• [Journal Article] Prognostic importance of the gross classification of hepatocellular carcinoma in living donor-related liver transplantation. (2010)
  • Author(s): Shirabe K, Aishima S, Taketomi A, Soejima Y, Uchiyama H, Kayashima H, Ninomiya M, Mano Y, Maehara Y.
  • Journal Title: Br J Surg. 98 Pages: 261-267
  • Peer Reviewed
• [Journal Article] p62+ hyaline inclusions in intrahepatic cholangiocarcinoma associated with viral hepatitis or alcoholic liver disease. (2010)
  • Author(s): Aishima S, Fujita N, Mano, Iguchi T, Taketomi A, Maehara Y, Oda Y, Tsuneyoshi M.
  • Journal Title: Am J Clin Pathol. 134 Pages: 457-465
  • NAID: 120005227181
  • Peer Reviewed
• [Journal Article] Pdcd4 expression in intraductal papillary mucinous neoplasm of the pancreas: its association with tumor progression and proliferation. (2010)
  • Author(s): Hayashi A, Aishima S, Miyasaka Y, Nakata K, Morimatsu K, Oda Y, Nagai E, Oda Y, Tanaka M, Tsuneyoshi M.
  • Journal Title: Hum Pathol. 41 Pages: 1507-1515
  • NAID: 120005227180
  • Peer Reviewed
• [Journal Article] Decreased expression of focal adhesion kinase is associated with a poor prognosis in extrahepatic bile duct carcinoma. (2010)
  • Author(s): Hayashi A, Aishima S, Inoue T, Nakata K, Morimatsu K, Nagai E, Oda Y, Tanaka M, Tsuneyoshi M.
  • Journal Title: Hum Pathol. 451 Pages: 859-866
  • Peer Reviewed
• [Journal Article] Down-regulation of artery in moderately differentiated hepatocellular carcinoma related to tumor development. (2010)
  • Author(s): Fujita N, Aishima S, Iguchi T, Nishihara Y, Yamamoto H, Taketomi A, Oda Y, Honda H, Tsuneyoshi M
  • Journal Title: Hum Pathol 41 Pages: 838-847
  • Peer Reviewed
• [Journal Article] S100P is a novel marker to identify intraductal papillary mucinous neoplasms. (2010)
  • Author(s): Nakata K, Nagai E, Ohuchida K, Hayashi A, Miyasaka Y, Aishima S, Oda Y, Mizumoto K, Tanaka M, Tsuneyoshi M
  • Journal Title: Hum Pathol 41 Pages: 824-831
  • Peer Reviewed
• [Journal Article] Clinicopathological Prognostic Factors After Hepatectomy for Patients with Mass-Forming Type Intrahepatic Cholangiocarcinoma: Relevance of the Lymphatic Invasion Index. (2010)
  • Author(s): Shirabe K, Mano Y, Taketomi A, Soejima Y, Uchiyama H, Aishima S, Kayashima H, Ninomiya M, Maehara Y
  • Journal Title: Ann Surg Oncol 17 Pages: 1816-1822
  • Peer Reviewed
• [Journal Article] p62+ Hyaline Inclusions in Intrahepatic Cholangiocarcinoma Associated With Viral Hepatitis or Alcoholic Liver Disease (2010)
  • Author(s): Aishima S, et al.
  • Journal Title: American Journal of Clinical Pathology Volume: 134 Pages: 457-465
  • NAID: 120005227181
  • Peer Reviewed
• [Journal Article] Decreased expression of focal adhesion kinase is associated with a poor prognosis in extrahepatic bile duct carcinoma. (2010)
  • Author(s): Hayashi A, Aishima S, et al.
  • Journal Title: Human Pathology Volume: 41 Pages: 859-866
  • Peer Reviewed
• [Journal Article] Decreased intratumoral arteries reflect portal tract destruction and aggressive characteristics in intrahepatic cholangiocarcinoma. (2009)
  • Author(s): Aishima S, et al.
  • Journal Title: Histopathology 54 Pages: 452-61
  • Peer Reviewed
• [Journal Article] CD10+ fibroblasts are more involved in the progression of hilar/extrahepatic cholangiocarcinoma than of peripheral intrahepatic cholangiocarcinoma. (2009)
  • Author(s): Nishihara Y, Aishima S, et al.
  • Journal Title: Histopathology 55 Pages: 423-431
  • Peer Reviewed
• [Presentation] 肝硬変に生じるBilINの病理学的特徴.JDDW2010 (2010)
  • Author(s): 相島慎一、間野洋平、調憲
  • Organizer: 第14回日本肝臓学会大会
  • Place of Presentation: 横浜
  • Year and Date: 2010-10-14
• [Presentation] 原発性肝癌の予後因子 (2010)
  • Author(s): 相島慎一、藤田展宏、間野洋平、調憲、武冨紹信、前原喜彦、小田義直
  • Organizer: 第14回日本肝臓学会大会
  • Place of Presentation: 横浜
  • Year and Date: 2010-10-14
• [Presentation] 肝内胆管癌の発育・進展メカニズムの病理学的解明.Pathological investigation of tumor growth and progression of intrahepatic cholangiocarcinoma. (2010)
  • Author(s): 相島慎一
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-23
• [Presentation] Pathological investigation of tumor growth and progression of intrahepatic cholangiocarcinoma (2010)
  • Author(s): Aishima S, et al.
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪市
  • Year and Date: 2010-09-23
• [Presentation] Intraductal papillary mucinous neoplasm(IPMN)におけるLiver intestinal cadherin発現の検討 (2010)
  • Author(s): 森松克哉、相島慎一、林晃史、小田康徳、小田義直
  • Organizer: 第99回日本病理学会総会
  • Year and Date: 2010-04-28
• [Presentation] 肝内胆管癌におけるS100P、Ezrin発現の意義 (2010)
  • Author(s): 相島慎一、藤田展宏、間野洋平、小田康徳、森松克哉、小田義直
  • Organizer: 第99回日本病理学会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-27
• [Presentation] Decreased intratumoral arteries reflect portal tract destruction and aggressive characteristics in intrahepatic cholangiocarcinoma. (2009)
  • Author(s): Aishima S, et al.
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜市(パシフィコ横浜)
  • Year and Date: 2009-10-02
• [Book] 病理形態学キーワード2010病理と臨床【臨時増刊号】28(第8章肝曩胞性病変) (2010)
  • Author(s): 相島慎一
• [Book] 肝癌(胆管嚢胞腺癌/胆管嚢胞腺腫腫瘍病理鑑別診断アトラス) (2010)
  • Author(s): 相島慎一
• [Remarks] ホームページ等
  • URL: http://www.surgpath.med.kyushu-u.ac.jp/ap/