Molecular-biological analysis and differential diagnosis in epithelioid sarcoma and malignant rhabdoid tumor
| Project/Area Number |
21790356
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Human pathology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 悪性ラブドイド腫瘍 / 類上皮肉腫 / SMARCB1/INI1 / microRNA / 小児軟部発生未分化肉腫 / SMARCBl/INI1 / 滑膜肉腫 / SMARCB1 / INI1 / Glypican 3 |
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| Research Abstract |
Epithelioid sarcoma(ES) and malignant rhabdoid tumor(MRT) are suggested to be distinct tumor entities with respect to the microRNA profiles. Meanwhile, pediatric undifferentiated sarcoma with loss of SMARCB1/INI1 protein expression, morphologically resembling malignant lymphoma, may have the same spectrum as MRT. Evaluation of glypican 3(GPC3) immunoexpression may be a useful diagnostic tool to distinguish ES from MRT. It is suggested that MRTs with glypican 3 overexpression may become a new target of GPC3 immunotherapy.
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Report
(4 results)
Research Products
(54 results)
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[Journal Article] Successful resection of an undifferentiated sarcoma in a child using a real-time surgical navigation system in an open magnetic resonance imaging operation room2011
Author(s)
Souzaki R, Kinoshita Y, Matsuura T, Tajiri T, Taguchi T, Ieiri S, Hong J, Uemura M, Konishi K, Tomikawa M, Tanoue K, Hashizume M, Koga Y, Suminoe A, Hara T, Kohashi K, et al
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Journal Title
J Pediatr Surg
Volume: 46
Issue: 3
Pages: 608-611
DOI
Related Report
Peer Reviewed
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[Presentation] 肝腫瘍の1例2010
Author(s)
孝橋賢一,(他)
Organizer
小児腫瘍分類委員会症例検討会
Place of Presentation
大阪市
Year and Date
2010-09-03
Related Report
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[Presentation] 肝腫瘍の1例2010
Author(s)
孝橋賢一, 他
Organizer
2010年度小児腫瘍分類委員会 症例検討会
Place of Presentation
大阪
Year and Date
2010-09-03
Related Report
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