Molecular-biological analysis and differential diagnosis in epithelioid sarcoma and malignant rhabdoid tumor

• Project/Area Number: 21790356
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Human pathology
• Research Institution: Kyushu University
• Principal Investigator: KOHASHI Kenichi 九州大学, 医学研究院, 助教 (10529879)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 悪性ラブドイド腫瘍 / 類上皮肉腫 / SMARCB1/INI1 / microRNA / 小児軟部発生未分化肉腫 / SMARCBl/INI1 / 滑膜肉腫 / SMARCB1 / INI1 / Glypican 3

Research Abstract

Epithelioid sarcoma(ES) and malignant rhabdoid tumor(MRT) are suggested to be distinct tumor entities with respect to the microRNA profiles. Meanwhile, pediatric undifferentiated sarcoma with loss of SMARCB1/INI1 protein expression, morphologically resembling malignant lymphoma, may have the same spectrum as MRT. Evaluation of glypican 3(GPC3) immunoexpression may be a useful diagnostic tool to distinguish ES from MRT. It is suggested that MRTs with glypican 3 overexpression may become a new target of GPC3 immunotherapy.

Research Products

• [Journal Article] Inhibin alpha and synaptophysin immunoreactivity in synovial sarcoma with granular cell features. (2012)
  • Author(s): Setsu N
  • Journal Title: Human Pathology Volume: 43 Issue: 6 Pages: 850-854
  • DOI: 10.1016/j.humpath.2011.07.012
  • Peer Reviewed
• [Journal Article] 上皮様軟部肉腫の鑑別診断 (2012)
  • Author(s): 孝橋賢一, 小田義直
  • Journal Title: 病理と臨床 Volume: 30 Pages: 154-59
• [Journal Article] 骨軟部腫瘍 (2012)
  • Author(s): 孝橋賢一, 小田義直
  • Journal Title: 最新医学 Volume: 67 Pages: 437-44
• [Journal Article] The Akt/mammalian target of rapamycin pathway is activated and associated with adverse prognosis in soft tissue leiomyosarcomas (2012)
  • Author(s): Setsu N, Yamamoto H, Kohashi K, Endo M, Matsuda S, Yokoyama R, Nishiyama K, Iwamoto Y, Dobashi Y, Oda Y
  • Journal Title: Cancer Volume: 118(6) Issue: 6 Pages: 1637-48
  • DOI: 10.1002/cncr.26448
  • Peer Reviewed
• [Journal Article] 上皮様軟部肉腫の鑑別診断 (2012)
  • Author(s): 孝橋賢一、小田義直
  • Journal Title: 病理と臨床 Volume: 30 Pages: 154-159
• [Journal Article] 骨軟部腫瘍 (2012)
  • Author(s): 孝橋賢一、小田義直
  • Journal Title: 最新医学 Volume: 67 Pages: 437-444
• [Journal Article] Surgical intervention strategies for pediatric ovarian tumors : experience with 60 cases at one institution (2012)
  • Author(s): Tajiri T, Souzaki R, Kinoshita Y, Yosue R, Kohashi K, et al
  • Journal Title: Pediatr Surg Int Volume: 28 Issue: 1 Pages: 27-31
  • DOI: 10.1007/s00383-011-3004-3
  • Peer Reviewed
• [Journal Article] Heterozygosity loss at 22q and lack of INI1gene mutation in gastrointestinal stromaltumor (2011)
  • Author(s): Yamamoto H, K ohashi K, et al.
  • Journal Title: Pathobiology Volume: 78 Issue: 3 Pages: 132-39
  • DOI: 10.1159/000323564
  • Peer Reviewed
• [Journal Article] Prognostic significance of p14^<ARF>, p15^<ISK4b>, and p16^<INK4a> inactivation in malignant peripheral nerve sheath tumors (2011)
  • Author(s): 遠藤誠
  • Journal Title: Clinical Cancer Research Volume: 17 Issue: 11 Pages: 3771-3782
  • DOI: 10.1158/1078-0432.ccr-10-2393
  • Peer Reviewed
• [Journal Article] Synchronized expressions of hepatic stellate cells and their transactivation and liver regeneration during liver injury in an animal model of cholestasis (2011)
  • Author(s): Alatas FS, Masumoto K, Matsuura T, Hayashida M, Saeki I, Kohashi K, et al
  • Journal Title: J Pediatr Surg Volume: 46 Issue: 12 Pages: 2284-2290
  • DOI: 10.1016/j.jpedsurg.2011.09.016
  • Peer Reviewed
• [Journal Article] Correlation between the number of segmental chromosome aberrations and the age at diagnosis of diploid neuroblastomas without MYCN amplification (2011)
  • Author(s): Souzaki R, Tajiri T, Teshiba R, Kinoshita Y, Yosue R, Kohashi K, et al
  • Journal Title: J Pediatr Surg Volume: 46 Issue: 12 Pages: 2228-2232
  • DOI: 10.1016/j.jpedsurg.2011.09.005
  • Peer Reviewed
• [Journal Article] High aromatase activity and overexpression of epidermal growth factor receptor in fibrolamellar hepatocellular carcinoma in a child (2011)
  • Author(s): Muramori K, Taguchi S, Taguchi T, Kohashi K, et al
  • Journal Title: J Pediatr Hematol Oncol Volume: 33 Issue: 5 Pages: e195-e197
  • DOI: 10.1097/mph.0b013e3182011676
  • Peer Reviewed
• [Journal Article] Successful resection of an undifferentiated sarcoma in a child using a real-time surgical navigation system in an open magnetic resonance imaging operation room (2011)
  • Author(s): Souzaki R, Kinoshita Y, Matsuura T, Tajiri T, Taguchi T, Ieiri S, Hong J, Uemura M, Konishi K, Tomikawa M, Tanoue K, Hashizume M, Koga Y, Suminoe A, Hara T, Kohashi K, et al
  • Journal Title: J Pediatr Surg Volume: 46 Issue: 3 Pages: 608-611
  • DOI: 10.1016/j.jpedsurg.2010.11.043
  • Peer Reviewed
• [Journal Article] Adenomatoidな所見を伴う気管支閉鎖症と肺葉外肺分画症との合併 (2011)
  • Author(s): 江角元史郎、澤田紀子、手柴理沙、永田公二、木下義晶、孝橋賢一, 他
  • Journal Title: 小児外科 Volume: 43 Pages: 1289-1293
  • Peer Reviewed
• [Journal Article] Successful resection of an undifferentiated sarcoma in a child using a real-time surgical navigation system in an open magnetic resonance imaging operation room (2011)
  • Author(s): Souzaki R, Kohashi K, et al.
  • Journal Title: Journal of Pediatric Surgery Volume: 46 Pages: 608-11
  • Peer Reviewed
• [Journal Article] Reduced expression of SMARCB 1/INI1 protein in synovial sarcoma (2010)
  • Author(s): Kohashi K, Oda Y, et al.
  • Journal Title: Mod Pathol Volume: 23 Issue: 7 Pages: 981-90
  • DOI: 10.1038/modpathol.2010.71
  • Peer Reviewed
• [Journal Article] Reduced expression of SMARCB1/INI1 protein in synovial sarcoma (2010)
  • Author(s): Kohashi K, et al.
  • Journal Title: Modern Pathology Volume: 23 Pages: 981-90
  • Peer Reviewed
• [Journal Article] Low-grade dedifferentiated liposarcoma of the neck : magnetic resonance imaging and pathological correlation (2010)
  • Author(s): Endo M, Kohashi K, et al.
  • Journal Title: Journal of Orthopaedic Science Volume: 15 Pages: 148-152
  • NAID: 10027403285
  • Peer Reviewed
• [Journal Article] Successful treatment of advanced pancreatoblastoma by a pylorus-preserving_ pancreatoduodenectomy after radiation and high-dose chemotherapy (2010)
  • Author(s): Souzaki R, Kohashi K, et al.
  • Journal Title: Pediatric surgery International Volume: 26 Pages: 1045-48
  • Peer Reviewed
• [Journal Article] Hedgehog signaling pathway in neuroblastoma differentiation (2010)
  • Author(s): Souzaki R, Kohashi K, et al.
  • Journal Title: Journal of Pediatric Surgery Volume: 45 Pages: 2299-304
  • Peer Reviewed
• [Journal Article] Concordance for neuroblastoma in monozygotic twins : case report and review of the literature (2010)
  • Author(s): Tajiri T, Kohashi K, et al.
  • Journal Title: Journal of Pediatric Surgery Volume: 45 Pages: 2312-16
  • Peer Reviewed
• [Journal Article] 小児軟部腫瘍の病理診断と遺伝子異常 (2009)
  • Author(s): 孝橋賢一, 田口智章, 小田義直
  • Journal Title: 日本小児科学会雑誌 Volume: 11 Pages: 1626-35
  • NAID: 10026276385
• [Journal Article] Re : Direct evidence of mutational inactivation of SMARCB1/INI1 in epithelioid sarcoma (2009)
  • Author(s): Kohashi K, Oda Y, et al.
  • Journal Title: Hum Pathol Volume: 40 Pages: 1362-64
• [Journal Article] Direct evidence of mutational inactivation of SMARCB1/INI1 in epithelioid sarcoma-Reply (2009)
  • Author(s): 孝橋賢一
  • Journal Title: Human Pathology 9 Pages: 1362-1364
  • Peer Reviewed
• [Journal Article] 小児軟部腫瘍の病理診断と遺伝子異常 (2009)
  • Author(s): 孝橋賢一
  • Journal Title: 日本小児科学会雑誌 11 Pages: 1626-1635
  • NAID: 10026276385
  • Peer Reviewed
• [Journal Article] Prognostic significance of p14ARF, p15INK4b and p16INK4a inactivation in malignant peripheral nerve sheath tumors
  • Author(s): Endo M, Kohashi K, et al.
  • Journal Title: Clinical Cancer Research Volume: (In Press)
  • Peer Reviewed
• [Journal Article] Reduced expression of SMARCB1/INI1 protein in synovial sarcoma
  • Author(s): 孝橋賢一
  • Journal Title: Modern Pathology (In Press)
  • Peer Reviewed
• [Presentation] 小児腎腫瘍(九州地区登録例)の新病理分類に基づく解析特に後腎芽細胞優位型 (2011)
  • Author(s): 木下義晶、田尻達郎、住江愛子、稲田浩子、八木實、柳井文男、財前善雄、西真範、猪俣裕紀洋、川上清、松藤凡、末延聡一、孝橋賢一, 他
  • Organizer: 日本小児血液・がん学会
  • Place of Presentation: 前橋
  • Year and Date: 2011-11-26
• [Presentation] 肝芽腫PRETEXT III、IV症例に対する外科治療戦略 (2011)
  • Author(s): 田尻達郎、代居良太、宗崎良太、木下義晶、古賀友紀、住江愛子、孝橋賢一, 他
  • Organizer: 日本小児血液・がん学会
  • Place of Presentation: 前橋
  • Year and Date: 2011-11-26
• [Presentation] 膵Solid-pseudopapillary tumorの臨床病理学的検討 (2011)
  • Author(s): 三好きな、孝橋賢一, 他
  • Organizer: 日本小児血液・がん学会
  • Place of Presentation: 前橋
  • Year and Date: 2011-11-26
• [Presentation] 神経芽腫MYCN非増幅症例におけるsegmental chromosome aberrationと年齢との相関 (2011)
  • Author(s): 宗崎良太、田尻達郎、代居良太、木下義晶、三好きな、孝橋賢一, 他
  • Organizer: 日本小児血液・がん学会
  • Place of Presentation: 前橋
  • Year and Date: 2011-11-26
• [Presentation] 多剤併用化学療法により重篤な横紋筋融解症を発症した胞巣型横紋筋肉腫の1例 (2011)
  • Author(s): 松崎寛司、古賀友紀、住江愛子、瓜生久美子、原寿郎、孝橋賢一, 他
  • Organizer: 日本小児血液・がん学会
  • Place of Presentation: 前橋
  • Year and Date: 2011-11-26
• [Presentation] 腹腔鏡下生検が有用であった肝多発性focal nodular hyperplasia (FNH)様病変 (2011)
  • Author(s): 代居良太、田尻達郎、林田真、家入里志、宗崎良太、木下義晶、孝橋賢一, 他
  • Organizer: 日本小児血液・がん学会
  • Place of Presentation: 前橋
  • Year and Date: 2011-11-25
• [Presentation] 奇形腫に類似した嚢胞様構造を呈した腎外性腎芽腫の1例 (2011)
  • Author(s): 廣瀬龍一郎、小幡聡、當寺ヶ盛学、有馬透、豊島里志、中村晶俊、孝橋賢一, 他
  • Organizer: 日本小児外科学会
  • Place of Presentation: 東京
  • Year and Date: 2011-07-22
• [Presentation] 精巣原発悪性腫瘍の2例 (2011)
  • Author(s): 宗崎良太、木下義晶、田尻達郎、代居良太、古賀友紀、住江愛子、孝橋賢一, 他
  • Organizer: 日本小児泌尿器科学会
  • Place of Presentation: 秋田
  • Year and Date: 2011-07-15
• [Presentation] 悪性末梢神経鞘腫瘍におけるAkt-mTORシグナル伝達経路の活性化と予後との関係 (2011)
  • Author(s): 遠藤誠、薛宇孝、高橋祐介、孝橋賢一, 他
  • Organizer: 日本整形外科学会骨・軟部腫瘍学術集会
  • Place of Presentation: 京都
  • Year and Date: 2011-07-14
• [Presentation] 小児外科領域における手術ナビゲーションの導入・実践 (2011)
  • Author(s): 宗崎良太、家入里志、田尻達郎、植村宗則、木下義晶、古賀友紀、住江愛子、孝橋賢一, 他
  • Organizer: 日本外科学会
  • Place of Presentation: (紙上開催)
  • Year and Date: 2011-05-25
• [Presentation] INI1蛋白欠失腫瘍群におけるglypican3発現 (2011)
  • Author(s): 孝橋賢一,(他)
  • Organizer: 日本病理学会
  • Place of Presentation: 横浜市
  • Year and Date: 2011-04-30
• [Presentation] INI1蛋白欠失腫瘍群におけるglypican 3発現 (2011)
  • Author(s): 孝橋賢一, 他
  • Organizer: 日本病理学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-04-30
• [Presentation] 悪性末梢神経鞘腫瘍における予後予測因子としてのp14、p15、p16不活性化の意義 (2011)
  • Author(s): 遠藤誠、孝橋賢一, 他
  • Organizer: 日本病理学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-04-30
• [Presentation] 肝腫瘍の1例 (2010)
  • Author(s): 孝橋賢一,(他)
  • Organizer: 小児腫瘍分類委員会症例検討会
  • Place of Presentation: 大阪市
  • Year and Date: 2010-09-03
• [Presentation] 肝腫瘍の1例 (2010)
  • Author(s): 孝橋賢一, 他
  • Organizer: 2010年度小児腫瘍分類委員会 症例検討会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-03
• [Presentation] 滑膜肉腫におけるSMARCB1/INI1蛋白発現 (2010)
  • Author(s): 孝橋賢一,(他)
  • Organizer: 日本整形外科学会骨軟部腫瘍学術集会
  • Place of Presentation: 東京
  • Year and Date: 2010-07-15
• [Presentation] 滑膜肉腫におけるSMARCB1/INI1蛋白発現 (2010)
  • Author(s): 孝橋賢一, 他
  • Organizer: 第43回日本整形外科学会骨軟部腫瘍学術集会
  • Place of Presentation: 東京
  • Year and Date: 2010-07-15
• [Presentation] 類奇形腫成分を伴った肝芽腫の1例 (2010)
  • Author(s): 孝橋賢一,(他)
  • Organizer: 九州地区小児固形悪性腫瘍研究会
  • Place of Presentation: 福岡市
  • Year and Date: 2010-02-27
• [Presentation] 類奇形腫成分を伴った肝芽腫の1例 (2010)
  • Author(s): 孝橋賢一
  • Organizer: 第39回小児固形悪性腫瘍研究会
  • Place of Presentation: 福岡県福岡市
  • Year and Date: 2010-02-27
• [Presentation] INI1蛋白陰性腫瘍群におけるGlypican3を用いた鑑別診断 (2009)
  • Author(s): 孝橋賢一,(他)
  • Organizer: 日本小児がん学会
  • Place of Presentation: 千葉県浦安市
  • Year and Date: 2009-11-27
• [Presentation] INI1蛋白欠失腫瘍群におけるGlypican 3を用いた鑑別診断 (2009)
  • Author(s): 孝橋賢一
  • Organizer: 第25回日本小児がん学会
  • Place of Presentation: 千葉県浦安市
  • Year and Date: 2009-11-27
• [Presentation] 先天性肺腫瘍の1例 (2009)
  • Author(s): 孝橋賢一,(他)
  • Organizer: 小児腫瘍分類委員会症例検討会
  • Place of Presentation: 東京
  • Year and Date: 2009-09-04
• [Presentation] 先天性肺腫瘍の1例 (2009)
  • Author(s): 孝橋賢一
  • Organizer: 2009年度小児腫瘍症例検討会
  • Place of Presentation: 東京都世田谷区
  • Year and Date: 2009-09-04
• [Book] 組織型と診断の実際その他の腫瘍類上皮肉腫.腫瘍病理鑑別診断アトラス軟部腫瘍 (2012)
  • Author(s): 孝橋賢一
  • Publisher: 文光堂
• [Book] Pediatric rhabdomyosarcoma : Role of cell cycle regulators alteration. Pediatric Cancer, Volume 2 Teratoid/Rhabdoid, Brain Tumors, and Glioma (2012)
  • Author(s): K ohashi K, et al
  • Publisher: Springer
• [Book] PEDIATRIC RHABDOMYOSARCOMA : ROLE OF CELL CYCLE REGULATORS ALTERATION, In : Hayat MA (eds), TUMORS OF THE CENTRAL NERVOUS SYSTEM
  • Author(s): Kohashi K, et al.
  • Publisher: Springer(In Press)
• [Book] IX.その他の腫瘍 2.類上皮肉腫,長谷川匡、小田義直、編集,腫瘍病理鑑別診断アトラス9.軟部腫瘍
  • Author(s): 孝橋賢一
  • Publisher: 文光堂(In Press)