Pentraxin 3 in atherosclerotic plaque reduces platelet thrombus formation under flow.

• Project/Area Number: 21790358
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Human pathology
• Research Institution: University of Miyazaki
• Principal Investigator: MORIGUCHI Sayaka 宮崎大学, 医学部, 助教 (90468041)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 循環器病理 / 血栓症

Research Abstract

Atherosclerotic plaque disruption with subsequent thrombus formation is a major cause of atherothrombosis, particularly in acute myocardinal infarction. Inflammatory biomarkers play an important rule, in atherothrombosis. In this study, we investigate the role of PTX3, a novel imflammatory biomarker : in cardiovascular event. PTX3 was localized in coronary plaque, and the expression was significantly increased in patients with unstable angina. PTX3 inhibited platelet aggregation, and significantly reduced platelet thrombus formation under flow condition. Thus, PTX3 may affect thrombus formation via a platelet antagonist after plaque disruption.

Research Products

• [Journal Article] Human C-reactive protein enhances thrombus formation after neointimal balloon injury in transgenic rabbits (2011)
  • Author(s): Matsuda S, Yamashita A, Sato Y
  • Journal Title: J Thromb Haemost Volume: 9 Pages: 201-208
  • Peer Reviewed
• [Journal Article] Coagulation and Inflammation (2011)
  • Author(s): 丸塚浩助
  • Journal Title: C&I Update DICの病理 Volume: 5 Pages: 1-6
• [Journal Article] Human C-reactive protein enhances thrombus formation after neointimal balloon injury in transgenic rabbits. (2011)
  • Author(s): 松田俊太郎
  • Journal Title: Journal of Thrombosis and Haemostasis. Volume: 9 Pages: 201-208
  • Peer Reviewed
• [Journal Article] Inhibition of factor XI reduces thrombus formation in rabbit jugular vein under endothelial denudation and/or blood stasis (2010)
  • Author(s): Takahashi M, Yamashita A, Moriguchi-Goto S
  • Journal Title: Thromb Res Volume: 125 Pages: 464-470
  • Peer Reviewed
• [Journal Article] Inhibition of factor XI reduces thrombus formation in rabbit jugular vein under endothelial denudation and/or blood stasis. (2010)
  • Author(s): 高橋良咲
  • Journal Title: Thrombosis Research. Volume: 125 Pages: 464-470
  • Peer Reviewed
• [Journal Article] Critical role of von Willebrand factor and platelet interaction in venous thromboembolism (2009)
  • Author(s): Takahashi M, Yamashita A, Moriguchi-Goto S
  • Journal Title: Histol Histopathol Volume: 24 Pages: 1391-1398
  • Peer Reviewed
• [Presentation] Elevates plasma levels of factor VIII enhance thrombus formation though excess thrombin generation in rabbit jugular vein (2011)
  • Author(s): 杉田千泰
  • Organizer: XXIII Congress of International Society on Thrombosis and Haemostasis
  • Place of Presentation: 日本(京都)
  • Year and Date: 2011-07-27
• [Presentation] Elevated plasma levels of factor VIII enhance thrombus formation though excess thrombin generation in rabbit jugular vein (2011)
  • Author(s): 杉田千泰
  • Organizer: XXIII Congress of International Society on Thrombosis and Haemostasis
  • Place of Presentation: 日本(京都)
  • Year and Date: 2011-07-27
• [Presentation] Pentraxin 3 in atherosclerotic plaque reduces platelet thrombus formation under flow (2010)
  • Author(s): 盛口清香
  • Organizer: 6th Asian-Pacific Society on Thrombosis and Hemostasis
  • Place of Presentation: インドネシア(バリ)
  • Year and Date: 2010-10-16
• [Presentation] Pentraxin 3 in atherosclerotic plaque reduces platelet thrombus formation under flow. (2010)
  • Author(s): 盛口清香
  • Organizer: 第6回アジア太平洋血栓止血学会
  • Place of Presentation: インドネシア(バリ)
  • Year and Date: 2010-10-16
• [Patent(Industrial Property Rights)] ペントラキシン3またはペントラキシン3変異体を含む、血小板凝集抑制剤、血栓形成剤および循環器疾患の治療薬 (2008)
  • Inventor(s): 浅田祐士郎, 畠山金太, 今村卓郎, 後藤清香, 児玉龍彦, 相良三奈
  • Industrial Property Rights Holder: 浅田祐士郎, 畠山金太, 今村卓郎, 後藤清香, 児玉龍彦, 相良三奈
  • Industrial Property Number: 2008-255988
  • Filing Date: 2008-10-01