| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Research Abstract |
Atherosclerotic plaque disruption with subsequent thrombus formation is a major cause of atherothrombosis, particularly in acute myocardinal infarction. Inflammatory biomarkers play an important rule, in atherothrombosis. In this study, we investigate the role of PTX3, a novel imflammatory biomarker : in cardiovascular event. PTX3 was localized in coronary plaque, and the expression was significantly increased in patients with unstable angina. PTX3 inhibited platelet aggregation, and significantly reduced platelet thrombus formation under flow condition. Thus, PTX3 may affect thrombus formation via a platelet antagonist after plaque disruption.
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