Function analysis of SGSM family in NURR1 related pathogenesis of Parkinson's disease

Research Project

Project/Area Number	21790367
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Human pathology
Research Institution	Keio University
Principal Investigator	YANG Hao Keio University, 先導研究センター, 助教 (10464992)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords	脳・神経 / パーキンソン病 / SGSM / RABファミリー / RAPファミリー / NURR1 / 小胞輸送
Research Abstract	SGSM family proteins interact with NURR1, encoded by the pathogenic gene of Parkinson's disease, and associate with intracellular vesicular transportation. The function of SGSM family proteins was analyzed by molecular biological approaches and the results indicated that SGSM2 was localized at trans-Golgi network and involved in the clathrin-dependent vesicular transportation. The association between SGSM2 and small G protein RAB family proteins was investigated by mammalian 2-hybrid system and the results suggested that SGSM2 show certain specificity for different RAB family proteins.

Report

(3 results)