Roles of HES1 and DEC2, newly identified transcriptional targets of GLI1, in pancreatic carcinogenesis.
| Project/Area Number |
21790370
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Human pathology
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| Research Institution | Aichi Medical University |
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Principal Investigator |
INAGUMA Shingo Aichi Medical University, 医学部, 講師 (80410786)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 分子病理 / 膵臓癌 / シグナル伝達 / ヘッジホッグ / 転写因子 / GLI1 |
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| Research Abstract |
We identified DEC2 as one of the direct transcriptional targets of GLI1, a downstream transcription factor of Hedgehog signaling pathway, via CACCC-box-like elements localized between -1126 and -1117 in the DEC2 promoter. We also showed that one of the mismatch repair gene MLH1 was down-regulated by GLI1-induced DEC2. We propose the possibility that Shh-GLI1-DEC2 pathway represses MLH1 expression and could enhance gene alteration and genomic instability in pancreatic carcinogenesis.
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Report
(3 results)
Research Products
(10 results)
