| Project/Area Number |
21790378
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | Chiba University |
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Principal Investigator |
KAWAMURA Harukjyo Chiba University, 大学院・医学研究院, 助教 (70527902)
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| Co-Investigator(Renkei-kenkyūsha) |
IWANAGA Toshihiko 北海道大学, 組織細胞学分野, 教授 (10160128)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 糖尿病 / sDTラット / VEGF / 血管内皮細胞 / SDTラット |
|---|
| Research Abstract |
Vascular endothelial cells of SDT rat, a spontaneously diabetic model, showed enhanced response against VEGF in vitro. Pharmacological inhibition of the excessive signaling suppressed pancreatic b cell loss and development of diabetes in SDT rats. These data suggests a new mechanism of diabetes development that VEGF secreted from pancreatic b cells induces excessive signaling in pancreatic vascular endothelial cells, which causes vascular dysfunction or increase in secretion factors injuring pancreatic b cells, leading to the pancreatic b cell death.
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