| Project/Area Number |
21790382
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
|---|
| Research Field |
Experimental pathology
|
|---|
| Research Institution | University of Fukui |
|---|
Principal Investigator |
NAGANUMA Seiji University of Fukui, 医学部, 助教 (50452123)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
|
|---|
| Keywords | 食道癌 / 扁平上皮癌 / EMT / マイクロRNA / ZEB / HGF / miR-200 family / TGF-β / miR-200ファミリー |
|---|
| Research Abstract |
Epithelial-mesenchymal transition (EMT) of tumor cells promoted by stimulation of Hepatocyte growth factor (HGF) is regulated by some microRNAs (miR-200 family) via ZEB1 and ZEB2, and actually in esophageal cancer tissue, we clarified upregulation of ZEB, and downregulation of miR-200 family at the invasion front. Also, our data indicate that knockdown of ZEB prevents induction of EMT and cancer invasion as well, providing a novel mechanistic insight into esophageal carcinogenesis and tumor progression.
|
