Investigation into differentiation effect of TGF beta for cancer stem cells in bone-metastatic prostate cancer cells

• Project/Area Number: 21790390
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Experimental pathology
• Research Institution: Nagoya City University
• Principal Investigator: SATO Shinya Nagoya City University, 大学院・医学研究科, 助教 (30464564)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 前立腺癌 / 癌幹細胞 / 骨微小環境 / 分化誘導 / TGFbeta / 分化 / ラット / CD44 / 薬剤耐性 / TGFβ / 分化誘導療法

Research Abstract

We raised the possibility of the existence of cancer stem cells in bone-metastatic prostate cancer cells. We also showed that prostate cancer cell proliferation was decreased by TGF beta1 receptor inhibitors in vivo and in vitro, and clarified the significance of TGF beta signaling regulation as a new prostate cancer therapy.

Research Products

• [Journal Article] Tranilast suppresses prostate cancer growth and osteoclast differentiation in vivo and in vitro (2010)
  • Author(s): Sato S, Takahashi S, Asamoto M, Naiki T, Naiki-Ito A, Asai K, Shirai T
  • Journal Title: The Prostate vol 70 Pages: 229-238
  • Peer Reviewed
• [Journal Article] Induction of apoptosis in the LNCaP human prostate carcinoma cell line and prostate adenocarcinomas of SV40T antigen transgenic rats by the Bowman-Birk inhibitor (2010)
  • Author(s): Tang M, Asamoto M, Ogawa K, Naiki-Ito A, Sato S, Takahashi S, Shirai T
  • Journal Title: Pathol Int vol 59 Pages: 790-796
  • NAID: 10027382149
  • Peer Reviewed
• [Journal Article] Traniast Suppresses Prostate Cancer Growth and Osteoclast Differentiation In Vivo and In Vitro (2010)
  • Author(s): 佐藤慎哉、白井智之, ら
  • Journal Title: The Prostate Volume: Vol.70 Pages: 229-238
  • Peer Reviewed
• [Journal Article] Transforming growth factor-beta signaling at the tumor-bone interface promotes mammary tumor growth and osteoclast activation (2009)
  • Author(s): Futakuchi M, Nannuru K.C, Varney ML, Sadanandam A, Nakao K, Asai K, Shirai T, Sato S, Singh RK
  • Journal Title: Cancer Science vol 100 Pages: 71-81
  • Peer Reviewed
• [Journal Article] Suppression of prostate cancer in a transgenic rat model viagamma-tocophenol activation of caspase signaling (2009)
  • Author(s): akahashi S, Takeshita K, Seeni A, Sugiura S, Tang M, Sato S, Shirai T
  • Journal Title: The Prostate vol 100 Pages: 71-81
  • Peer Reviewed
• [Presentation] Trial to identify cancer stem cells in primary and bone metastatic prostate cancers (2010)
  • Author(s): 佐藤慎哉、白井智之, ら
  • Organizer: 第69回日本癌学会
  • Place of Presentation: リーガロイヤルホテル(大阪府)
  • Year and Date: 2010-09-24
• [Presentation] 原発巣・骨転移巣における前立腺癌幹細胞同定の試み (2010)
  • Author(s): 佐藤慎哉
  • Organizer: 第69回日本癌学会
  • Place of Presentation: リーガロイヤルホテル大阪(大阪府)
  • Year and Date: 2010-09-24
• [Presentation] 骨微小環境における前立腺癌幹細胞の同定に向けた試み (2010)
  • Author(s): 佐藤慎哉、白井智之, ら
  • Organizer: 第99回日本病理学会
  • Place of Presentation: 京王プラザホテル(東京都)
  • Year and Date: 2010-04-28
• [Presentation] 骨微小環境における前立腺癌幹細胞の同定にむけた試み (2010)
  • Author(s): 佐藤慎哉
  • Organizer: 第99回日本病理学会
  • Place of Presentation: 京王プラザホテル(東京都)
  • Year and Date: 2010-04-28
• [Presentation] 前立腺癌骨微小環境における前立腺癌幹細胞同定の試み (2010)
  • Author(s): 佐藤慎哉
  • Organizer: 日本毒性病理学会
  • Place of Presentation: 石川県音楽堂(金沢市)
  • Year and Date: 2010-02-04
• [Presentation] 骨微小環境における前立腺癌幹細胞同定の試み (2010)
  • Author(s): 佐藤慎哉、白井智之, ら
  • Organizer: 第26回日本毒性病理学会
  • Place of Presentation: 石川県立音楽堂(石川県)
  • Year and Date: 2010-02-03