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The role of human ABH-8 in urothelial carcinoma

Research Project

Project/Area Number 21790392
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Experimental pathology
Research InstitutionNara Medical University

Principal Investigator

SHIMADA Keiji  Nara Medical University, 医学部, 講師 (90336850)

Co-Investigator(Renkei-kenkyūsha) KONISHI Noboru  奈良県立医科大学, 医学部, 教授 (20145832)
TSUJIKAWA Kazutake  大阪大学, 薬学研究科, 教授 (10207376)
OUJI Yukiteru  奈良県立医科大学, 医学部, 助教 (50343421)
DEVELASCO Marco  近畿大学, 医学部, 助教 (20449838)
TANAKA Motoyoshi  近畿大学, 医学部, 講師 (30347562)
FUJIMOTO Kiyohide  奈良県立医科大学, 医学部, 准教授 (50264867)
HIRAO Yoshihiko  奈良県立医科大学, 医学部, 教授 (00133207)
Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords腫瘍 / 尿路上皮癌 / hABH-8 / ALKBH-8 / 活性酸素種 / 膀胱尿路上皮癌 / アポトーシス / 免疫組織化学 / hALKBH-8 / NADPH oxidase
Research Abstract

We found for the first time that a novel DNA repair protein, hABH-8 promotes survival of human urothelial carcinoma cells through up-regulating generation of reactive oxygen species, moreover, the expression of hABH-8 is a useful marker to predict clinical development of urinary bladder cancer.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (32 results)

All 2011 2010 2009 Other

All Journal Article (14 results) (of which Peer Reviewed: 13 results) Presentation (17 results) Remarks (1 results)

  • [Journal Article] ALKBH3, a human AlkB homologue, contributes to cell survival in human non-small-cell lung cancer.2011

    • Author(s)
      Tasaki M, Shimada K, et al.
    • Journal Title

      Br J Cancer.

      Volume: 104 Pages: 700-706

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of syndecan-1 (CD138) in cell survival of human urothelial carcinoma.2010

    • Author(s)
      Shimada K, Nakamura M, De Velasco MA, Tanaka M, Ouji Y, Miyake M, Fujimoto K, Hirao K, Konishi N.
    • Journal Title

      Cancer Sci. Vol.101, No.1

      Pages: 155-160

    • NAID

      10027199949

    • Related Report
      2010 Final Research Report
  • [Journal Article] Role of syndecan-1 (CD138) in cell survival of human urothelial carcinoma.2010

    • Author(s)
      Shimada K, et al.
    • Journal Title

      Cancer Science

      Volume: 101 Pages: 155-160

    • NAID

      10027199949

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel human AlkB homologue, ALKBH8, contributes to human bladder cancer progression.2009

    • Author(s)
      Shimada K, Nakamura M, Anai S, De Velasco M, Tanaka M, Tsujikawa K, Ouji Y, Konishi N.
    • Journal Title

      Cancer Res. Vol.69, No.7

      Pages: 3157-3164

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Treatable fluctuating mental impairment in a patient with Bardet-Biedl syndrome2009

    • Author(s)
      Tonomura, Y., Shimada, K., et al
    • Journal Title

      Clin Newol Neurosurg 111

      Pages: 102-104

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical analysis of neurcendcerine differentiation in prostate cancer2009

    • Author(s)
      Ishida, E., Shimada, K., et al
    • Journal Title

      Pathobiology 76

      Pages: 30-38

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel human AlkB homologue, ALKBH8, contributes to human bladder cancer progression2009

    • Author(s)
      Shimada, K., Konishi, N., et al
    • Journal Title

      Cancer Res 69

      Pages: 3157-3164

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of urothelial carcinoma with triple variants featuring nested, plasmacytoid, and lipoid cell morphology2009

    • Author(s)
      Shimada, K., Konishi, N., et al
    • Journal Title

      Diagn Cytopathol 37

      Pages: 272-276

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Syndecan-1, a new target molecule involved in progression of androgen-independent prostate cancer2009

    • Author(s)
      Shimada, K., Konishi, N., et al
    • Journal Title

      Cancer Sci 100

      Pages: 1248-1254

    • NAID

      10027192115

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinicopathological diagnosis of gliomas by genotype analysis2009

    • Author(s)
      Nakamura, M., Shimada, K., et al
    • Journal Title

      Brain Nerve 61

      Pages: 773-780

    • NAID

      40016747526

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protein kinase C γ, a protein causative for dominant ataxia, negatively regulates nuclear import of recessive-ataxia-related aprataxin2009

    • Author(s)
      Asai, H., Shimada, K., et al
    • Journal Title

      Hum Mol Genet 18

      Pages: 3533-3543

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation status of fas-associated death domain-containing protein regulates telomerase activity and strongly correlates with prostate cancer outcomes2009

    • Author(s)
      Matsumura, Y., Shimada, K., et al
    • Journal Title

      Pathobiology 76

      Pages: 293-302

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 診断に苦慮したメラニン産生が少ない膣前庭部悪性黒色腫の1例2009

    • Author(s)
      武田麻衣子, 島田啓司, 他
    • Journal Title

      日本臨床細胞学会雑誌 48

      Pages: 386-389

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical importance of B7-H3 expression in human pancreatic cancer2009

    • Author(s)
      Yamato, I., Shimada, K., et al
    • Journal Title

      Br J Cancer 101

      Pages: 1709-1716

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 拡大前立腺全摘術30例の経験2009

    • Author(s)
      岡島英二郎, 島田啓司, 他
    • Organizer
      第25回前立腺シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2009-12-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] Syndecan-1(CD138)を介した前立腺癌進展メカニズムの検討2009

    • Author(s)
      島田啓司, 小西登, 他
    • Organizer
      第25回前立腺シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2009-12-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] The role of syndecan-1 (CD138) in progression of human urinary bladder cancer2009

    • Author(s)
      Shimada, K., Nakamura, M., Marco A. De Velasco, Tanaka, M., Konishi, N.
    • Organizer
      第68回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-02
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Expression of human ABH families in non-small cell lung carcinoma2009

    • Author(s)
      Tasaki, M., Shimada, K., et al
    • Organizer
      第68回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] The phosphorylation status of FADD in biopsy specimens is associated with biochemical recurrence after prostatectomy2009

    • Author(s)
      Ikeda, T., Shimada, K., et al
    • Organizer
      第68回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] Analysis of the genes associated with premature senescence in prostate cancer and stromal cells of treated cases2009

    • Author(s)
      Ishida, E., Shimada, K., et al
    • Organizer
      第68回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] Response to temozolomide in malignant gliomas with histological heterogeneity2009

    • Author(s)
      Nakamura, M., Shimada, K., et al
    • Organizer
      第68回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] Clinical importance and therapeutic potential of PCA-1 expression in pancreatic cancer2009

    • Author(s)
      Yamato, I., Shimada, K., et al
    • Organizer
      第68回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] Paget様膀胱上皮内癌の一例2009

    • Author(s)
      池枇呂子, 島田啓司, 他
    • Organizer
      第50回日本臨床細胞学会総会春期大会
    • Place of Presentation
      東京
    • Year and Date
      2009-06-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 前立腺治療後の上皮細胞および間質細胞における遺伝子変異の検討2009

    • Author(s)
      中村光利, 島田啓司, 他
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都
    • Year and Date
      2009-05-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] 膀胱癌における新規遺伝子ヒトABH-8の機能解析2009

    • Author(s)
      大嶋正人, 島田啓司, 中村光利, 田崎正人, 辻川和丈, 小西登
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都
    • Year and Date
      2009-05-02
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 膀胱癌におけるCD138(Syndecan-1)発現の分子病理学的意義について2009

    • Author(s)
      島田啓司, 中村光利, 田崎正人, 小西登
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都
    • Year and Date
      2009-05-02
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 非小細胞肺癌におけるhABHファミリーの発現2009

    • Author(s)
      田崎正人, 島田啓司, 他
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都
    • Year and Date
      2009-05-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 術前無治療の前立腺全摘症例におけるリン酸化FADD発現の臨床病理学的意義2009

    • Author(s)
      池田朋博, 島田啓司, 他
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都
    • Year and Date
      2009-05-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 膀胱に発生したextranodal marginal zone lymphomaの一例2009

    • Author(s)
      石田英和, 島田啓司, 他
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都
    • Year and Date
      2009-05-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] 年齢別PSAカットオフ値および体積・年齢別生検本数ノモグラムを用いた前立腺生検の試み2009

    • Author(s)
      田中宣道, 島田啓司, 他
    • Organizer
      第97回日本泌尿器科学会総会
    • Place of Presentation
      岡山
    • Related Report
      2009 Annual Research Report
  • [Presentation] 前立腺全摘標本における分子生物学的生化学的再発予測因子の検討2009

    • Author(s)
      穴井智, 島田啓司, 他
    • Organizer
      第97回日本泌尿器科学会総会
    • Place of Presentation
      岡山
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ

    • URL

      http://www.naramed-u.ac.jp/~2path/index.html

    • Related Report
      2010 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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