The role of human ABH-8 in urothelial carcinoma
| Project/Area Number |
21790392
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | Nara Medical University |
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Principal Investigator |
SHIMADA Keiji Nara Medical University, 医学部, 講師 (90336850)
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| Co-Investigator(Renkei-kenkyūsha) |
KONISHI Noboru 奈良県立医科大学, 医学部, 教授 (20145832)
TSUJIKAWA Kazutake 大阪大学, 薬学研究科, 教授 (10207376)
OUJI Yukiteru 奈良県立医科大学, 医学部, 助教 (50343421)
DEVELASCO Marco 近畿大学, 医学部, 助教 (20449838)
TANAKA Motoyoshi 近畿大学, 医学部, 講師 (30347562)
FUJIMOTO Kiyohide 奈良県立医科大学, 医学部, 准教授 (50264867)
HIRAO Yoshihiko 奈良県立医科大学, 医学部, 教授 (00133207)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 腫瘍 / 尿路上皮癌 / hABH-8 / ALKBH-8 / 活性酸素種 / 膀胱尿路上皮癌 / アポトーシス / 免疫組織化学 / hALKBH-8 / NADPH oxidase |
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| Research Abstract |
We found for the first time that a novel DNA repair protein, hABH-8 promotes survival of human urothelial carcinoma cells through up-regulating generation of reactive oxygen species, moreover, the expression of hABH-8 is a useful marker to predict clinical development of urinary bladder cancer.
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Report
(3 results)
Research Products
(32 results)
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[Journal Article] A novel human AlkB homologue, ALKBH8, contributes to human bladder cancer progression.2009
Author(s)
Shimada K, Nakamura M, Anai S, De Velasco M, Tanaka M, Tsujikawa K, Ouji Y, Konishi N.
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Journal Title
Cancer Res. Vol.69, No.7
Pages: 3157-3164
Related Report
Peer Reviewed
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