Complement receptor 2 is expressed by neural progenitor cells and regulates adult hippocampal neurogenesis in mice

• Project/Area Number: 21790393
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Experimental pathology
• Research Institution: Juntendo University
• Principal Investigator: HASEGAWA Maiko Juntendo University, 医学部, 助教 (20516637)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 補体受容体 / 神経新生 / 神経幹細胞

Research Abstract

Complement receptor 2 (CR2) is expressed by neural progenitor cells and inhibits differentiation to neural lineage. Adult neurogenesis was increased in the dentate gyrus of CR2 deficient mice, indicating that neurogenesis might be promoted by down-regulating CR2 signaling.

Research Products

• [Journal Article] Complement receptor 2 is expressed in neural progenitor cells and regulates adult hippocampal neurogenesis.
  • Author(s): Hasegawa-Moriyama M, Fukuhara T, Britchgi M, Villeda SA, Narasimhan R, Molina HD, Wyss-Coray T
  • Journal Title: Journal of Neuroscience in press
  • Peer Reviewed
• [Journal Article] Complement receptor 2 is expressed in neural progenitor cells and regulates adult hippocampal neurogenesis.
  • Author(s): Hasegawa-Moriyama M, Fukuhara T, Britschgi M, Villeda SA, Narasimhan R, Molina HD, Wyss-Coray T
  • Journal Title: Journal of Neuroscience Volume: (In press)
  • Peer Reviewed
• [Presentation] Complement receptor 2 is expressed by neural progenitor cells and regulates adult hippocampal neurogenesis in mice. (2010)
  • Author(s): T.Fukuhara, M.Moriyama, M.Britschgi, S.A.Villeda, R.Narasimhan, H.D.Molina, T.Wyss-Coray
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: Kobe, Japan
• [Presentation] Complement receptor 2 is expressed in neural progenitor cells and regulates adult hippocampal neurogenesis.
  • Author(s): Fukuhara T , Moriyama M, Britchgi M, Villeda SA, Narasimhan R, Molina HD, Wyss-Coray T
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: Kobe, Japan