CAMDI, a novel DISC1-binding protein, is required for radial migration
| Project/Area Number |
21790394
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
FUKUDA Toshifumi Tokyo University of Pharmacy and Life Science, 生命科学部, 助教 (50372313)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | CAMDI / Myosin / DISC1 / 神経 / 移動 / 脳 / 中心体 / 層構造 / 統合失調症 / 大脳皮質 / 神経細胞移動 / 子宮内遺伝子導入法 |
|---|
| Research Abstract |
This study has identified a novel disrupted in schizophrenia 1 (DISC1)-interacting protein, named CAMDI after coiled-coil protein associated with myosin II and DISC1. Knockdown of CAMDI revealed severely impaired radial migration. Interestingly, one single nucleotide polymorphism of the CAMDI gene (R828W) is identified. Furthermore, mice with overexpression of R828W in neurons exhibit an impaired radial migration. Our findings indicate that CAMDI is required for radial during neuronal development.
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Report
(3 results)
Research Products
(25 results)
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[Journal Article] A mitochondrial ubiquitin ligase MITOL controls cell toxicity of polyglutamine-expanded protein.2011
Author(s)
Sugiura, A., Yonashiro, R., Fukuda, T., Matsushita, N., Nagashima, S., Inatome, R., Yanagi, S.
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Journal Title
Mitochondrion 11
Pages: 139-146
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[Journal Article] Distinct regulation of mitochondrial localization and stability of two human Sirt5 isoforms.2011
Author(s)
Matsushita, N., Yonashiro, R., Ogata, Y., Sugiura, A., Nagashima, S., Fukuda, T., Inatome, R., Yanagi, S.
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Journal Title
Genes Cells 16
Pages: 190-202
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[Journal Article] Phospholipase Cδ3 regulates RhoA/Rho kinase signaling and neurite outgrowth.2011
Author(s)
Kouchi, Z., Igarashi, T., Shibayama, N., Inanobe, S., Sakurai, K., Yamaguchi, H., Fukuda, T. Yanag,i S., Nakamura, Y., Fukami, K.
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Journal Title
J.Biol.Chem. 286
Pages: 8459-8471
Related Report
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[Journal Article] Mitochondrial ubiquitin ligase MITOL ubiquitinates mutant SOD1 and attenuates mutant SOD1-induced ROS generation.2009
Author(s)
Yonashiro, R., Sugiura, A., Miyachi, M., Fukuda, T., Matsushita, N., Inatome, R., Ogata, Y., Suzuki, T., Dohmae, N., Yanagi, S.
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Journal Title
Mol.Biol.Cell 20
Pages: 4524-4530
Related Report
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