New Tyrosine kinase inhibitor for thyroid medullary carcinoma treatment

• Project/Area Number: 21790395
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Experimental pathology
• Research Institution: Aichi Medical University
• Principal Investigator: KAWAI Kumi 愛知医科大学, 医学部, 講師 (50362231)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 甲状腺がん / RET / 遺伝子操作動物 / チロシンキナーゼインヒビター / 癌 / 甲状腺髄様がん / キナーゼ阻害剤 / モデルマウス

Research Abstract

The purpose of this study was to demonstrate the effect of 2 new tyrosine kinase inhibitors against RET. Both drug inhibited RET phosphorylation and downstream signaling cascade in a dose-dependent manner. Furthermore, they suppressed cell growth, cell migration and invasion effectively. When medullary thyroid carcinoma model mice was treated with these drugs, significant reduction in thyroid tumor size was observed.

Research Products

• [Journal Article] Revisiting a medical case of "stinging" in the human oral cavity caused by ingestion of raw squid(Cephalopoda : Teuthida): new data on the functioning of squid's spermatophores (2012)
  • Author(s): Jose Eduardo A. R. Marian, Yukihiro Shiraki, Kumi Kawai, Sawako Kojima, Yasuhiko Suzuki and Kenzo Ono
  • Journal Title: Zoomorphology Volume: (in press)
  • Peer Reviewed
• [Journal Article] Stinging in the oral cavity caused by ingestion of the sperm bags of a squid : A case report (2011)
  • Author(s): Yukihiro Shiraki, Kumi Kawai, Sawako Kojima, Yasuhiko Suzuki and Kenzo Ono
  • Journal Title: Pathol Int Volume: 61 Pages: 749-751
  • NAID: 10031185151
  • Peer Reviewed
• [Journal Article] Ret finger protein inhibits muscle differentiation by modulating serum response factor and enhancer of polycomb1 (2011)
  • Author(s): Hae Jin Kee, Ju-Ryoung Kim, Hosouk Joung, Nakwon Choe, Song Eun Lee, Gwang Hyeon Eom, Jeong Chul Kim, Stefan H Geyer, Mayumi Jijiwa, Takuya Kato, Kumi Kawai, Wolfgang J Weninger, Sang-Beom Seo, Kwang-Il Nam, Myung Ho Jeong, Masahide Takahashi and Hyun Kook
  • Journal Title: Cell Death Differ Volume: 19 Pages: 121-131
  • Peer Reviewed
• [Journal Article] 多発性内分泌腫瘍症(MEN) (2011)
  • Author(s): 川井久美、今井常夫、高橋雅英
  • Journal Title: 病理と臨床 Volume: 29 Pages: 711-717
• [Journal Article] Loss of Sprouty2 partially rescues renal hypoplasia and stomach hypoganglionosis but not intestinal aganglionosis in Ret Y1062F mutant mice (2011)
  • Author(s): Rieko Miyamoto, Mayumi, Jijiwa, Masato Asai, Kumi Kawai, Maki Ishida-Takagishi, Shinji Mii, Naoya Asai, Atsushi Enomoto, Yoshiki Murakumo, Akihiko Yoshimura and Masahide Takahashi
  • Journal Title: Developmental Biololgy Volume: 349 Pages: 160-168
  • Peer Reviewed
• [Journal Article] Ret finger protein inhibits muscle differentiation by modulating serum response factor and enhancer of polycomb1 (2011)
  • Author(s): Hae Jin Kee
  • Journal Title: Cell Death & Differentiation Volume: 19 Issue: 1 Pages: 121-131
  • DOI: 10.1038/cdd.2011.72
  • Peer Reviewed
• [Journal Article] Stinging in the oral cavity caused by ingestion of the sperm bags of a squid : A case report (2011)
  • Author(s): Yukihiro Shiraki
  • Journal Title: Pathology International Volume: 61 Issue: 12 Pages: 749-751
  • DOI: 10.1111/j.1440-1827.2011.02722.x
  • Peer Reviewed
• [Journal Article] Loss of Sprouty2 partially rescues renal hypoplasia and stomach hypo-ganglionosis but not intestinal aganglionosis in Ret Y1062F mutant mice (2011)
  • Author(s): Rieko Miyamoto
  • Journal Title: Developmental Biology Volume: 349巻 Pages: 160-168
  • Peer Reviewed
• [Journal Article] Pleasure and Tullia Lindsten Maintenance of the relative proportion of oligodendrocytes to axons even in the absence of BAX and BAK (2009)
  • Author(s): Kumi Kawai, Takayuki Itoh, Aki Itoh, Makoto Horiuchi, Kouji Wakayama, Peter Bannerman, James Y Garbern, David
  • Journal Title: European Journal of Neuroscience Volume: 30 Pages: 2030-2031
  • Peer Reviewed
• [Journal Article] Maintenance of the relative proportion of oligodendrocytes to axons even in the absence of BAX and BAK (2009)
  • Author(s): Kawai K.
  • Journal Title: Eur.J.Neurosci. 30 Pages: 2030-2041
  • Peer Reviewed
• [Presentation] 甲状腺髄様癌とRET遺伝子の分子生物学 (2011)
  • Author(s): 川井久美
  • Organizer: 第44回甲状腺外科学会学術集会
  • Place of Presentation: 米子BIGSHIP(鳥取)
  • Year and Date: 2011-10-07
• [Presentation] オリゴデンドロサイトの発生制御におけるBAX/BAKの役割の解析 (2009)
  • Author(s): 川井久美
  • Organizer: 第98回 日本病理学会総会
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2009-05-01
• [Presentation] Rat グリオーマ組織内に存在する bipotent な分化能を有する細胞の同定 (2009)
  • Author(s): 黒川景
  • Organizer: 第98回 日本病理学会総会
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2009-05-01
• [Remarks]
  • URL: http://www.aichi-med-u.ac.jp/univ/medic/lecture2/10.html
• [Remarks]
  • URL: http://www.aichi-med-u.ac.jp/univ/medic/lecture2/10.html