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Investigation of transcription factors that regulate development of Plasmodium gametocytes.

Research Project

Project/Area Number 21790403
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Parasitology (including Sanitary zoology)
Research InstitutionMie University

Principal Investigator

KANEKO Izumi  Mie University, 大学院・医学系研究科, 助教 (20515720)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsマラリア / 転写因子
Research Abstract

We identified two transcription factors of malaria parasites (AP2-G1 and Ap2-G2) that regulate sexual development of gametocytes. We investigated binding sites of these transcription factors on the genome with ChIP-seq (Chromatin immunoprecipitation followed by high-throughput DNA sequencing) and identified candidate sequences for their cis-acting elements. Our study indicated that these transcription factors regulate gene expression independently or cooperatively and suggested that other regulatory factors are involved in the gene regulation by these transcription factors.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (11 results)

All 2011 2010 2009

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (3 results) Book (2 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 2 results)

  • [Journal Article] Functional identification of the Plasmodium centromere and generation of a Plasmodium artificial chromosome.2010

    • Author(s)
      Iwanaga S, Khan SM, Kaneko I, Christodoulou Z, Newbold C, Yuda M, Janse CJ, Waters AP.
    • Journal Title

      Cell Host Microbe 18;7(3)

      Pages: 245-255

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional identification of the Plasmodium centromere and generation of a Plasmodium artificial chromosome.2010

    • Author(s)
      Iwanaga S, Khan SM, Kaneko I, Christodoulou Z, Newbold C, Yuda M, Janse CJ, Waters AP.
    • Journal Title

      Cell Host Microbe

      Volume: 18;7(3) Pages: 245-55

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcription Factor AP2-Sp and its Target Genes in Malarial Sporozoites.2009

    • Author(s)
      Yuda M, Iwanaga S, Shigenobu S, Kato T,Kaneko I.
    • Journal Title

      Molecular Microbiology. 75

      Pages: 854-863

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transcription Factor AP2-Sp and its Target Genes in Malarial Sporozoites.2009

    • Author(s)
      Yuda M, Iwanaga S, Shigenobu S, Kato T, Kaneko I.
    • Journal Title

      Molecular Microbiology. 75

      Pages: 854-863

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] ChIP-seq法を用いたマラリア原虫転写因子AP2-Oの新規標的遺伝子の同定2010

    • Author(s)
      金子伊澄、加藤知美、岩永史朗、油田正夫
    • Organizer
      第79回寄生虫学会
    • Place of Presentation
      旭川市(大雪クリスタルホール)
    • Related Report
      2010 Final Research Report
  • [Presentation] ChIP-seq法を用いたマラリア原虫転写因子AP2-Oの新規標的遺伝子の同定2010

    • Author(s)
      金子伊澄
    • Organizer
      寄生虫学会
    • Place of Presentation
      旭川市大雪クリスタルホール
    • Related Report
      2010 Annual Research Report
  • [Presentation] ChIP-seq法を用いたマラリア原虫転写因子結合部位のgenome wideな解析2009

    • Author(s)
      金子伊澄・岩永史朗・加藤知美・油田正夫
    • Organizer
      第78回寄生虫学会
    • Place of Presentation
      法政大学
    • Related Report
      2010 Final Research Report
  • [Book] 感染症-ウイルス・細菌・寄生虫の感染戦略(実験医学、増刊)2009

    • Author(s)
      油田正夫、金子伊澄
    • Publisher
      羊土社
    • Related Report
      2010 Final Research Report
  • [Book] 実験医学、増刊「感染症-ウイルス・細菌・寄生虫の感染戦略」2009

    • Author(s)
      油田正夫、金子伊澄
    • Publisher
      羊土社
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 熱帯マラリア原虫への新規な直接遺伝子導入法2011

    • Inventor(s)
      岩永史朗・油田正夫・金子伊澄
    • Industrial Property Rights Holder
      国立大学法人三重大学
    • Filing Date
      2011-03-26
    • Related Report
      2010 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 熱帯マラリア原虫への新規な直接遺伝子導入法2011

    • Inventor(s)
      岩永史朗・油田正夫・金子伊澄
    • Industrial Property Rights Holder
      国立大学法人三重大学
    • Filing Date
      2011-03-26
    • Related Report
      2010 Annual Research Report
    • Overseas

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Published: 2009-04-01   Modified: 2016-04-21  

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