Investigation of transcription factors that regulate development of Plasmodium gametocytes.
| Project/Area Number |
21790403
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Mie University |
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Principal Investigator |
KANEKO Izumi Mie University, 大学院・医学系研究科, 助教 (20515720)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | マラリア / 転写因子 |
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| Research Abstract |
We identified two transcription factors of malaria parasites (AP2-G1 and Ap2-G2) that regulate sexual development of gametocytes. We investigated binding sites of these transcription factors on the genome with ChIP-seq (Chromatin immunoprecipitation followed by high-throughput DNA sequencing) and identified candidate sequences for their cis-acting elements. Our study indicated that these transcription factors regulate gene expression independently or cooperatively and suggested that other regulatory factors are involved in the gene regulation by these transcription factors.
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Report
(3 results)
Research Products
(11 results)
