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Host range of human malaria parasites

Research Project

Project/Area Number 21790404
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Parasitology (including Sanitary zoology)
Research InstitutionKyoto University (2010)
Osaka University (2009)

Principal Investigator

HAYAKAWA Toshiyuki  Kyoto University, 霊長類研究所, 助教 (80418681)

Co-Investigator(Renkei-kenkyūsha) TANABE Kazuyuki  大阪大学, 微生物病研究所, 特任教授 (40047410)
HIRAI Hirohisa  京都大学, 霊長類研究所, 教授 (10128308)
Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywordsマラリア / 原虫 / 宿主域 / 宿主特異性 / 宿主
Research Abstract

Human malaria parasites (Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, and Plasmodium ovale) are widely believed to infect only humans as a natural host. We report for the first time the identification of P.malariae in two chimpanzees. These two infected chimpanzees were imported into Japan thirty years ago and have been asymptomatic to the present while in Japan. This indicates that chimpanzees can be a natural host of P. malariae.
Importantly, this study also note that human malaria parasite has been maintained in nonhuman primates in nonendemic country, and thus has significance in public health. Currently, nonhuman primates are not included in the target for malaria control. This study reinforces the importance of a survey of human malaria parasites in nonhuman primates not only in endemic countries but also in nonendemic countries, and should contribute to better understanding and improved control of human malaria.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (8 results)

All 2010 2009 Other

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (4 results) Remarks (2 results)

  • [Journal Article] Identification of Plasmodium malariae, a human malaria parasite2009

    • Author(s)
      早川敏之、有末伸子、鵜殿俊史、平井啓久、Jetsumon Sattabongkot、遠山知子、坪井敬文、堀井俊宏、田邉和裄
    • Journal Title

      PLoS ONE in imported chimpanzees 4

    • Related Report
      2010 Final Research Report
  • [Journal Article] Identification of Plasmodium malariae, a human malaria parasite, in imported chimpanzees2009

    • Author(s)
      早川敏之
    • Journal Title

      PLoS ONE VOL.4

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 現生マラリア原虫の起源での急速な多様化(マラリアビッグバン)2010

    • Author(s)
      早川敏之
    • Organizer
      日本進化学会第12回東京大会
    • Place of Presentation
      東京
    • Year and Date
      2010-08-03
    • Related Report
      2010 Final Research Report
  • [Presentation] 現生マラリア原虫の起源での急速な多様化(マラリアビッグバン)2010

    • Author(s)
      早川敏之
    • Organizer
      日本進化学会第12回東京大会
    • Place of Presentation
      東京工業大学 大岡山キャンパス(東京都)
    • Year and Date
      2010-08-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] マラリア原虫のミトコンドリアゲノムの進化2009

    • Author(s)
      早川敏之
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      兵庫(神戸)
    • Year and Date
      2009-10-21
    • Related Report
      2010 Final Research Report
  • [Presentation] マラリア原虫のミトコンドリアゲノムの進化2009

    • Author(s)
      早川敏之
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Year and Date
      2009-10-21
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.biken.osaka-u.ac.jp/act/act_tanabe.php

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.biken.osaka-u.ac.jp/act/act_tanabe.php

    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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