Elucidation of the mechanisms that malaria parasites evade from the host's immune system by polymorphism and duplication of immune target genes in malaria species
| Project/Area Number |
21790405
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | The University of Tokyo (2010)
Osaka University (2009) |
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Principal Investigator |
SAWAI Hiromi The University of Tokyo, 大学院・医学系研究科, 特任研究員 (60377124)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 原虫 / 進化 / スポロゾイト表面抗原 / 三日熱マラリア原虫 / 分子進化 / メロゾイト表面抗原 |
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| Research Abstract |
The purpose of this study is to elucidate the evolutionary trait of three molecules (MSP-1 : merozoite surface protein 1, CSP : circumsporozoite protein, and AMA-1 : apical membrane antigen 1) and to obtain clues to understand the adaptation strategy of malaria parasites against their hosts. This study presented evidence of a signature for ancestral positive selection on msp1 of malaria parasites. Estimated time frame of these ancestral lineages was between 3.0 and 6.3 million years ago, which coincide well with the period of radiation events of Asian macaques. It is plausible that Asian macaque malaria parasites radiated along with radiation events of host monkey species. I also obtained a signature for diversifying selection at specific amino acid sites in these parasite species. However, amino acid substitutions in these sites/regions greatly differed among the parasite species. Although ama1 seemed to be similar evolutionary history to msp1, it was suggested that csp received the mechanism to evade from the various host's immune system by amino acid repeats.
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Report
(3 results)
Research Products
(22 results)
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[Journal Article] Ferreira, Ananias A.Escalante, Franck Prugnolle, Anders Bjorkman, Anna Farnert, Akira Kaneko, Toshihiro Horii, Andrea Manica, Hirohisa Kishino and Francois Balloux.Plasmodium falciparum accompanied the human expansion out of Africa.2010
Author(s)
Kazuyuki Tanabe, Toshihiro Mita, Thibaut Jombart, Anders Eriksson, Shun Horibe, Nirianne Palacpac, Lisa Ranford-Cartwright, Hiromi Sawai, Naoko Sakihama, Hiroshi Ohmae, Masatoshi Nakamura, Marcelo U.
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Journal Title
Current Biology 20
Pages: 1283-1289
Related Report
Peer Reviewed
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[Journal Article] Lineage-specific positive selection at the merozoite surface protein 1 (msp1) locus of Plasmodium vivax and related simian malaria parasites.2010
Author(s)
Hiromi Sawai, Hiroto Otani, Nobuko Arisue, Nirianne Palacpac, Leonardo de Oliveira Martins, Sisira Pathirana, Shiroma Handunnetti, Satoru Kawai, Hirohisa Kishino, Toshihiro Horii, Kazuyuki Tanabe.
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Journal Title
BMC Evolutionary Biology 10
Pages: 52-52
Related Report
Peer Reviewed
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[Journal Article] Divergence of mitochondrial genome structure in the apicomplexan parasites, Babesia and Theileria.2010
Author(s)
Kenji Hikosaka, Yoh-ichi Watanabe, Naotoshi Tsuji, Kiyoshi Kita, Hiroe Kishine, Nobuko Arisue, Nirianne Marie Q. Palacpac, Shin-ichiro Kawazu, Hiromi Sawai, Toshihiro Horii, Ikuo Igarashi, Kazuyuki Tanabe.
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Journal Title
Molecular Biology and Evolution 27
Pages: 1107-1116
Related Report
Peer Reviewed
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