Analysis of menbrane dynamics and identification of target signal to parasitophorous vacuole menbrane of malaria parasite.

Research Project

Project/Area Number	21790407
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Parasitology (including Sanitary zoology)
Research Institution	Tottori University
Principal Investigator	IRIKO Hideyuki Tottori University, 医学部, 助教 (60346674)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords	マラリア / 原虫 / 寄生胞膜 / 感染症
Research Abstract	During the process of invasion, maralia parasite initiates the formation of a membrane, the so-called parasitophorous vacuole membrane (PVM). PVM is associated with host-parasite interaction. In this study, we analysed membrane dynamics and target signal to PVM in malaria parasite. We succeed in visualization of PVM and deternimation of forming period of tubulovesicular membrane network and circular clefts.