The suppression of severe pathology during coinfection with Plasmodium berghei ANKA and Plasmodium berghei XAT
| Project/Area Number |
21790410
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Research Collaborator |
KOBAYASHI Fumie 杏林大学, 医学部, 教授 (20118889)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | マラリア原虫 / 複合感染 / 病態重症化の抑制 / IL-10 / Pb ANKA / PbXAT / 脳症抑制効果 / 自然免疫 / TLR / 病原体認識 / Pb XAT / 原虫血症 / 摘脾 / IgM / 脳マラリア / 熱帯熱マラリア原虫 / 三日熱マラリア原虫 / マラリア原虫複合感染 / IL-10 Receptor |
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| Research Abstract |
In this study, it is demonstrated that IL-10 Receptor(R)+cells and IL-10 play a crucial role for suppressing the severe pathology such as cerebral malaria during coinfection with Plasmodium berghei(Pb) ANKA and Pb XAT. It is seemed that IL-10R+cells and IL-10 were induced by the specific immune response against Pb XAT. In addition, the suppression of severe pathology during coinfection with Pb ANKA and Pb XAT was independent of spleen and Toll-like receptor.
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Report
(4 results)
Research Products
(25 results)
