The suppression of severe pathology during coinfection with Plasmodium berghei ANKA and Plasmodium berghei XAT

• Project/Area Number: 21790410
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Parasitology (including Sanitary zoology)
• Research Institution: Kyorin University
• Principal Investigator: NIIKURA Mamoru 杏林大学, 医学部, 助教 (30407019)
• Research Collaborator: KOBAYASHI Fumie 杏林大学, 医学部, 教授 (20118889)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: マラリア原虫 / 複合感染 / 病態重症化の抑制 / IL-10 / Pb ANKA / PbXAT / 脳症抑制効果 / 自然免疫 / TLR / 病原体認識 / Pb XAT / 原虫血症 / 摘脾 / IgM / 脳マラリア / 熱帯熱マラリア原虫 / 三日熱マラリア原虫 / マラリア原虫複合感染 / IL-10 Receptor

Research Abstract

In this study, it is demonstrated that IL-10 Receptor(R)+cells and IL-10 play a crucial role for suppressing the severe pathology such as cerebral malaria during coinfection with Plasmodium berghei(Pb) ANKA and Pb XAT. It is seemed that IL-10R+cells and IL-10 were induced by the specific immune response against Pb XAT. In addition, the suppression of severe pathology during coinfection with Pb ANKA and Pb XAT was independent of spleen and Toll-like receptor.

Research Products

• [Journal Article] Role of interleukin-10 in malaria : focusing on coinfection with lethal and nonlethal murine malaria parasites (2011)
  • Author(s): Niikura M., Inoue I., Kobayashi F
  • Journal Title: Journal of Biomedicine and Biotechnology
  • Peer Reviewed
• [Journal Article] Role of IL-10 in malaria : focusing on coinfection with lethal and nonlethal murine malaria parasites (2011)
  • Author(s): Mamoru Niikura
  • Journal Title: Journal of Biomedicine and Biotechnology Volume: 2011 Issue: 1 Pages: 383962-383962
  • DOI: 10.1155/2011/383962
  • Peer Reviewed
• [Journal Article] マラリア原虫複合感染と病態の重症化との関係 (2011)
  • Author(s): 新倉保
  • Journal Title: アニテックス Volume: 3月号(In press)
• [Journal Article] IL-10 plays a crucial role for the protection of experimental cerebral malaria by co-infection with non-lethal malaria parasites (2010)
  • Author(s): Niikura M., Kamiya S., Nakane A., Kita K., Kobayashi F
  • Journal Title: International Journal for Parasitology Volume: 40 Pages: 101-108
  • Peer Reviewed
• [Journal Article] IL-10 plays a crucial role for the protection of experimental cerebral malaria by co-infection with non-lethal malaria parasltes. (2010)
  • Author(s): 新倉保
  • Journal Title: International Journal for Parasitology Vol.4 Pages: 101-108
  • Peer Reviewed
• [Presentation] γδT細胞による樹状細胞活性化を介したマラリア原虫感染防御機構の解明 (2012)
  • Author(s): 井上信一, 新倉保, 川上泰, 内田明彦, 小林富美惠
  • Organizer: 第81回日本寄生虫学会大会
  • Place of Presentation: 西宮
• [Presentation] Plasmodium berghei ANKAが引き起こす脳症の抑制に関する研究 (2011)
  • Author(s): 新倉保, 井上信一, 小林富美惠
  • Organizer: 第40回杏林医学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-19
• [Presentation] マラリア感染が明らかにする自然免疫リンパ球の新たな役割 (2011)
  • Author(s): 井上信一, 新倉保, 小林富美惠
  • Organizer: 第71回日本寄生虫学東日本支部大会
  • Place of Presentation: 東京
  • Year and Date: 2011-10-01
• [Presentation] HowγδT cells mediate protective immunity to Plasmodium berghei XAT infection (2011)
  • Author(s): Inoue S., Niikura M., Yokota N., Kawakami Y., Uchida A., Kobayashi F
  • Organizer: The 5th Immunoparasitology Meeting
  • Place of Presentation: Osaka
• [Presentation] γδT細胞による樹状細胞活性化を介したマラリア原虫感染防御機構の解明 (2011)
  • Author(s): 井上信一, 新倉保, 横田夏紀, 小林富美惠
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] γδT cells regulate supply and activation of immune cells during blood-stage Plasmodium berghei XAT infection (2011)
  • Author(s): Inoue S., Niikura M., Yokota N., Kawakami Y., Uchida A., Kobayashi F
  • Organizer: The 17th Japanese-German Cooperative Symposium on Protozoan Diseases
  • Place of Presentation: Nara
• [Presentation] Spleen is not essential for development of liver injury during Plasmodium berghei infection (2011)
  • Author(s): Niikura M., Inoue S., Kobayashi F
  • Organizer: International Union of Microbiological Societies 2011 Congress(IUMS)
  • Place of Presentation: Sapporo, Japan
• [Presentation] マラリア原虫複合感染による原虫血症増悪機序の解析 (2011)
  • Author(s): 新倉保, 井上信一, 小林富美惠
  • Organizer: 第80回日本寄生虫学会大会・第22回日本臨床寄生虫学会大会
  • Place of Presentation: 東京
• [Presentation] マラリア原虫複合感染による原虫血症増悪機序の解析 (2011)
  • Author(s): 新倉保
  • Organizer: 第80回日本寄生虫学会大会
  • Place of Presentation: 東京
• [Presentation] Spleen is not essential for development of liver injury during Plasmodium berghei infection (2011)
  • Author(s): Mamoru Niikura
  • Organizer: International Union of Microbiological Societies Sapporo 2011
  • Place of Presentation: Sapporo
• [Presentation] Spleen plays a pathological role during Plasmodium berghei ANKA infection (2010)
  • Author(s): Niikura M., Inoue S., Kobayashi F
  • Organizer: 第70回日本寄生虫学東日本支部大会
  • Place of Presentation: 栃木
  • Year and Date: 2010-10-02
• [Presentation] マラリア原虫複合感染における脾臓の役割 (2010)
  • Author(s): 新倉保
  • Organizer: 第3回原虫感染免疫研究会
  • Place of Presentation: 熱帯医学研究所(長崎県)
  • Year and Date: 2010-03-26
• [Presentation] The influence of splenectomy on the outcome of coinfection with lethal Plasmodium berghei ANKA and nonlethal P. berghei XAT (2010)
  • Author(s): Niikura M., Inoue S., Kobayashi F
  • Organizer: The 2010 XIIth International Congress of Parasitology(ICOPA)
  • Place of Presentation: Melbourne, Australia
• [Presentation] マウスマラリア原虫複合感染において脾臓は原虫血症の増悪に関与する (2010)
  • Author(s): 新倉保, 井上信一, 小林富惠
  • Organizer: 第18回分子寄生虫ワークショップ
  • Place of Presentation: 群馬
• [Presentation] マウスマラリア原虫複合感染における脾臓の役割 (2010)
  • Author(s): 新倉保, 小林富美惠
  • Organizer: 第3回原虫感染免疫研究会
  • Place of Presentation: 長崎
• [Presentation] The influence of splenectomy on the outcome of coinfection with lethal Plasmodium berghei ANKA and nonlethal P.berghei XAT (2010)
  • Author(s): Niikura M.
  • Organizer: XIIth International Congress of Parasitology (ICOPA)
  • Place of Presentation: Melbourne, Australia
• [Book] マラリア原虫複合感染と病態の重症化との関係 (2011)
  • Author(s): 新倉保, 小林富美惠
  • Publisher: アニテックス
• [Remarks] 杏林大学医学部感染症学寄生虫学部門HP
  • URL: http://www.kyorin-u.ac.jp/univ/user/medicine/did/parasit/p_index.html
• [Remarks]
  • URL: http://www.kyorin-u.ac.jp/univ/user/medicine/did/parasit/p_index.html
• [Remarks] 杏林大学医学部感染症学講座寄生虫学部門HP;
  • URL: http://www.kyorin-u.ac.jp/univ/user/medicine/did/parasit/p_index.html