| Project/Area Number |
21790414
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ASHIDA Hiroshi The University of Tokyo, 医科学研究所, 助教 (10535115)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 赤痢菌 / エフェクター / ユビキチン / 炎症 / 病原細菌 / NF-κB / 免疫応答 / 感染 |
|---|
| Research Abstract |
IpaH9.8, a Shigella effector possessing E3 ubiquitin ligase activity, dampens the NF-κB-mediated inflammatory response to the bacterial infection. IpaH9.8 targets NEMO/IKKγ for polyubiquitination, and consequently, the polyubiquitinated-NEMO underwent proteasome-dependent degradation and perturbed the NF-κB activation. Since NEMO is essential for NF-κB activation, the polyubiquitination and degradation of NEMO during Shigella infection is a novel bacterial strategy to modulate host inflammatory responses and promote bacterial infection.
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