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Analysis of Shigella type III effector mediated downregulation mechanism of host inflammatory response.

Research Project

Project/Area Number 21790414
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Bacteriology (including Mycology)
Research InstitutionThe University of Tokyo

Principal Investigator

ASHIDA Hiroshi  The University of Tokyo, 医科学研究所, 助教 (10535115)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords赤痢菌 / エフェクター / ユビキチン / 炎症 / 病原細菌 / NF-κB / 免疫応答 / 感染
Research Abstract

IpaH9.8, a Shigella effector possessing E3 ubiquitin ligase activity, dampens the NF-κB-mediated inflammatory response to the bacterial infection. IpaH9.8 targets NEMO/IKKγ for polyubiquitination, and consequently, the polyubiquitinated-NEMO underwent proteasome-dependent degradation and perturbed the NF-κB activation. Since NEMO is essential for NF-κB activation, the polyubiquitination and degradation of NEMO during Shigella infection is a novel bacterial strategy to modulate host inflammatory responses and promote bacterial infection.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (18 results)

All 2011 2010 2009 Other

All Journal Article (8 results) (of which Peer Reviewed: 4 results) Presentation (2 results) Book (6 results) Remarks (2 results)

  • [Journal Article] Shigella deploy multiple countermeasures against host innate immune responses.2011

    • Author(s)
      Ashida H, Ogawa M, Kim M, Suzuki S, Sanada T, Punginelli C, Mimuro H, Sasakawa C.
    • Journal Title

      Curr Opin in Microbiol. 14

      Pages: 16-23

    • Related Report
      2010 Final Research Report
  • [Journal Article] Shigella deploy multiple countermeasures against host innate immune responses.2011

    • Author(s)
      Ashida H, Ogawa M, Kim M, Suzuki S, Sanada T, Punginelli C, Mimuro H, Sasakawa C
    • Journal Title

      Current Opinion in Microbioly.

      Volume: 14 Pages: 16-23

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A bacterial E3 ubiquitin ligase IpaH9.8 effector targets NEMO/IKK_γ to dampen the host NF-_κB-mediated inflammatory response.2010

    • Author(s)
      Ashida H, Kim M, Schmidt-Supprian M, Ma A, Ogawa M, Sasakawa C.
    • Journal Title

      Nat.Cell.Biol. 12

      Pages: 66-73

    • Related Report
      2010 Final Research Report
  • [Journal Article] Bacterial interactions with the host epithelium: bacterial countermeasures that disrupt intrinsic epithelial barrier function.2010

    • Author(s)
      Kim M, Ashida H, Ogawa M, Mimuro H, Yoshikawa Y, Sasakawa C.
    • Journal Title

      Cell Host & Microbe. 8

      Pages: 20-35

    • Related Report
      2010 Final Research Report
  • [Journal Article] Bacterial interactions with the host epithelium : bacterial countermeasures that disrupt intrinsic epithelial barrier function.2010

    • Author(s)
      Kim M, Ashida H, Ogawa M, Mimuro H, Yoshikawa Y, Sasakawa C
    • Journal Title

      Cell Host & Microbe

      Volume: 8 Pages: 20-35

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKγ to dampen the host NF-κB-mediated inflammatory response2010

    • Author(s)
      Ashida H, Kim M, Schmidt-Supprian M, Ma A, Ogawa M, Sasakawa C
    • Journal Title

      Nature Cell Biology 12

      Pages: 66-73

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Shigella infection of intestinal epithelium and circumvention of the host innate defense system.2009

    • Author(s)
      Ashida H, Ogawa M, Mimuro H, Sasakawa C.
    • Journal Title

      Curr Top Microbiol Immunol. 337

      Pages: 231-55

    • Related Report
      2010 Final Research Report
  • [Journal Article] Shigella infection of intestinal epithelium and circumvention of the host in nate defense system2009

    • Author(s)
      Ashida H, Ogawa M, Mimuro H, Sasakawa C
    • Journal Title

      Current Topics Microbioly Immunoly 337

      Pages: 231-255

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKK_γ・ to dampen the host NF-_κ・B-mediated inflammatory response.2010

    • Author(s)
      Hiroshi Ashida, Chihiro Sasakawa.
    • Organizer
      第10回日韓国際微生物学シンポジウム
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2010-03-26
    • Related Report
      2010 Final Research Report
  • [Presentation] A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKKγ to dampen the host NF-κB-mediated inflammatory response2010

    • Author(s)
      Hiroshi Ashida, Chihiro Sasakawa
    • Organizer
      第10回 日韓国際微生物学シンポジウム
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2010-03-26
    • Related Report
      2009 Annual Research Report
  • [Book] 感染・炎症・免疫 vol.40, No.32010

    • Author(s)
      芦田浩、笹川千尋
    • Related Report
      2010 Final Research Report
  • [Book] 実験医学 vol.28, No.82010

    • Author(s)
      芦田浩、笹川千尋
    • Related Report
      2010 Final Research Report
  • [Book] 感染・炎症・免疫2010

    • Author(s)
      芦田浩、笹川千尋
    • Publisher
      医薬の門社
    • Related Report
      2010 Annual Research Report
  • [Book] 実験医学2010

    • Author(s)
      芦田浩、笹川千尋
    • Publisher
      羊土社
    • Related Report
      2010 Annual Research Report
  • [Book] 実験医学増刊 感染症-ウイルス・細菌・寄生虫の感染戦略2009

    • Author(s)
      芦田浩、笹川千尋
    • Related Report
      2010 Final Research Report
  • [Book] 実験医学増刊 感染症-ウイルス・細菌・寄生虫の感染戦略2009

    • Author(s)
      芦田浩、笹川千尋
    • Publisher
      羊土社
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.ims.u-tokyo.ac.jp/imsut/jp/research/papers/post_19.php

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.u-tokyo.ac.jp/public/public01_211214_j.html

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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