| Project/Area Number |
21790416
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Kyoto University |
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Principal Investigator |
TSUCHIYA Kohsuke Kyoto University, 医学研究科, 助教 (50437216)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | インフラマソーム / AIM2 / NLRP3 / ASC / リステリア / 細胞内寄生菌 / NLRC4 / 自然免疫 / カスパーゼ1 / DNA / Nod-like receptor |
|---|
| Research Abstract |
Listeria monocytogenes invades the cytoplasm of macrophages and induces the activation of caspase-1 and the subsequent maturation of IL-1β and IL-18. Although apoptosis-associated speck-like protein containing a caspase-activating and recruitment domain (ASC), an adaptor protein of Nod-like receptors, has been shown to play an essential role in inducing this cellular response to L. monocytogenes, the mechanism has not been fully elucidated. In this study, we demonstrated that absent in melanoma 2 (AIM2), a cytosolic DNA receptor, plays an important role in the activation of caspase-1 during L. monocytogenes infection.
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