| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Research Abstract |
I have studied about in vivo suppression of the toxicity in the invasive M-1 group A Streptococcal isolates, using mouse infection model. As results
(1) I could partially suppressed the toxicity in an invasive M-1 group A Streptococcal isolate, suppressing the NADase activity of Nga protein which is secreted toxin;
(2) I have presented the supportive evidence that Nga (also known as SPN) has a NADase-independent function;
(3) I provided other potential targets to suppress the Streptococcal virulence.
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