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In vivo suppression of the toxicity in the invasive M-1 group A Streptococcal isolates

Research Project

Project/Area Number 21790425
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Bacteriology (including Mycology)
Research InstitutionNagoya City University

Principal Investigator

TATSUNO Ichiro  名古屋市立大学, 大学院・医学研究科, 講師 (50311642)

Project Period (FY) 2009 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
KeywordsA 群連鎖球菌 / A 群レンサ球菌 / 人喰いバクテリア / レンサ球菌 / 連鎖球菌 / NADase / LPS / 蛍光 / Nga / IFS
Research Abstract

I have studied about in vivo suppression of the toxicity in the invasive M-1 group A Streptococcal isolates, using mouse infection model. As results
(1) I could partially suppressed the toxicity in an invasive M-1 group A Streptococcal isolate, suppressing the NADase activity of Nga protein which is secreted toxin;
(2) I have presented the supportive evidence that Nga (also known as SPN) has a NADase-independent function;
(3) I provided other potential targets to suppress the Streptococcal virulence.

Report

(5 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (27 results)

All 2013 2012 2011 2010 2009

All Journal Article (17 results) (of which Peer Reviewed: 17 results) Presentation (10 results)

  • [Journal Article] Characterization of NADase-inactive NAD^+ glycohydrolase in Streptococcus pyogenes.2013

    • Author(s)
      Tatsuno I, Isaka M, Hasegawa T.
    • Journal Title

      Advances in Microbiology.

      Volume: 3(1) Issue: 01 Pages: 91-100

    • DOI

      10.4236/aim.2013.31015

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Partial loss of CovS function in Streptococcus pyogenes causes severe invasive disease.2013

    • Author(s)
      Tatsuno I, Okada R, Zhang Y, Isaka M, Hasegawa T.
    • Journal Title

      BMC Res Notes.

      Volume: 6(1) Issue: 1 Pages: 126-126

    • DOI

      10.1186/1756-0500-6-126

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Variation in M protein production among Streptococcus pyogenes strains according to emm genotype.2011

    • Author(s)
      Matsumoto M, Suzuki M, Hirose K, Hiramatsu R, Minagawa H, Minami M, Tatsuno I, Okamoto A, Ohta M, Hasegawa T.
    • Journal Title

      Microbiol Immunol

      Volume: 55(6) Issue: 6 Pages: 379-87

    • DOI

      10.1111/j.1348-0421.2011.00329.x

    • NAID

      10031121482

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of two-component sensor proteins involved in response to acid stimuli in Streptococcus pyogenes.2011

    • Author(s)
      Ichikawa M, Minami M, Isaka M, Tatsuno I, Hasegawa T
    • Journal Title

      Microbiology

      Volume: 157 Issue: 11 Pages: 3187-94

    • DOI

      10.1099/mic.0.050534-0

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of two-component sensor proteins involved in the response to acid stimuli in Streptococcus pyogenes2011

    • Author(s)
      Ichikawa M, Minami M, Isaka M, Tatsuno I, et al
    • Journal Title

      Microbiology

      Volume: 157 Pages: 3187-3194

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Variation in M protein production among Streptococcus pyogenes strains according to emm genotype.2011

    • Author(s)
      松本昌門、立野一郎, (7番目)
    • Journal Title

      Microbiol Immunol

      Volume: (In press)

    • NAID

      10031121482

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clindamycin-induced CovS-mediated regulation of the production of virulent exoproteins streptolysin O, NAD glycohydrolase, and streptokinase in Streptococcus pyogenes2010

    • Author(s)
      Minami M, Kamimura T, Isaka M, Tatsuno I, Ohta M, Hasegawa T
    • Journal Title

      Antimicrob Agents Chemother

      Volume: 54 Issue: 1 Pages: 98-102

    • DOI

      10.1128/aac.00804-09

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of a virulence-associated and cell-wall-located DNase of Streptococcus pyogenes2010

    • Author(s)
      Hasegawa T, Minami M, Okamoto A, Tatsuno I, Isaka M, Ohta M
    • Journal Title

      Microbiology

      Volume: 156 Issue: 1 Pages: 184-190

    • DOI

      10.1099/mic.0.031955-0

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of Streptococcus pyogenes isolated from balanoposthitis patients presumably transmitted by penile-oral sexual intercourse2010

    • Author(s)
      Minami M, Wakimoto Y, Matsumoto M, Matsui H, Kubota Y, Okada A, Isaka M, Tatsuno I, Tanaka Y, Hasegawa T
    • Journal Title

      Curr Microbiol

      Volume: 61 Issue: 2 Pages: 101-105

    • DOI

      10.1007/s00284-010-9581-x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detection of invasive protein profile of Streptococcus pyogenes M1 isolates from pharyngitis patients2010

    • Author(s)
      Hasegawa T, Okamoto A, Kamimura T, Tatsuno I, Hashikawa S, Yabutani M, Matsumoto M, Yamada K, Isaka M, Minami M, Ohta M
    • Journal Title

      APMIS

      Volume: 118 Issue: 3 Pages: 167-78

    • DOI

      10.1111/j.1600-0463.2009.02574.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] NADase as a target molecule of in vivo suppression of the toxicity in the invasive M-1 group A Streptococcal isolates2010

    • Author(s)
      Tatsuno I, Isaka M, Minami M, Hasegawa T
    • Journal Title

      BMC Microbiol

      Volume: 10 Issue: 1 Pages: 144-144

    • DOI

      10.1186/1471-2180-10-144

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] NADase as a target molecule of in vivo suppression of the toxicity in the invasive M-1 group A Streptococcal isolates.2010

    • Author(s)
      立野一郎, (他3名)
    • Journal Title

      BMC Microbiol.

      Volume: 10 Pages: 144-152

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of Streptococcus pyogenes Isolated from Balanoposthitis Patients Presumably Transmitted by Penile-OralSexual Intercourse2010

    • Author(s)
      南正明、立野一郎, (8番目)
    • Journal Title

      Curr Microbiol.

      Volume: 61 Pages: 101-105

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of invasive protein profile of Streptococcus pyogenes M1 isolates from pharyngitis patients.2010

    • Author(s)
      長谷川忠男、立野一郎(4番目)
    • Journal Title

      APMIS VOL.118

      Pages: 167-178

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of Streptococcus pyogenes Isolated from Balanoposthitis Patients Presumably Transmitted by Penile-Oral Sexual Intercourse2010

    • Author(s)
      南正明、立野一郎(8番目)
    • Journal Title

      Curr Microbiol. (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of virulence-associated and cell-wall-located DNase of Streptococcus pyogenes2010

    • Author(s)
      長谷川忠男、立野一郎(4番目)
    • Journal Title

      Microbiology 156

      Pages: 184-190

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The streptococcal inhibitor of complement(SIC) protects Streptococcus pyogenes from bacteriocin-like inhibitory substance(BLIS) from Streptococcus salivarius2009

    • Author(s)
      Minami M, Ohmori D, Tatsuno I, Isaka M, Kawamura Y, Ohta M, Hasegawa T
    • Journal Title

      FEMS Microbiol Lett

      Volume: 298 Issue: 1 Pages: 67-73

    • DOI

      10.1111/j.1574-6968.2009.01696.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] A群連鎖球菌二成分制御因子SPY1622のバイオフィルム形成機構の解析2013

    • Author(s)
      井坂雅徳
    • Organizer
      日本細菌学会
    • Place of Presentation
      幕張メッセ 国際会議場 (千葉県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] A群レンサ球菌における二成分制御系センサータンパク質の機能解析2013

    • Author(s)
      立野一郎
    • Organizer
      東海乳酸菌研究会
    • Place of Presentation
      中日パレス(愛知県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] A群レンサ球菌csrS遺伝子の変異と菌の病原性に関する研究2012

    • Author(s)
      立野一郎
    • Organizer
      日本細菌学会・中部支部総会
    • Place of Presentation
      金沢大学医学類十全講堂(石川県)
    • Year and Date
      2012-11-09
    • Related Report
      2012 Final Research Report
  • [Presentation] Analysis of two component regulatory systems in S. pyogenes2012

    • Author(s)
      立野一郎
    • Organizer
      第85回日本細菌学会
    • Place of Presentation
      長崎新聞文化ホール(長崎県)
    • Year and Date
      2012-03-29
    • Related Report
      2012 Final Research Report
  • [Presentation] Analysis of two component regulatory systems in S.pyogenes2012

    • Author(s)
      立野一郎, 他4名
    • Organizer
      日本細菌学会
    • Place of Presentation
      長崎新聞文化ホール(長崎県)
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] S.pyogenes二成分制御系因子SPY1622の酸感受性およびバイオフィルム形成の作用機序2012

    • Author(s)
      長谷川忠雄、井坂雅徳、立野一郎, 他3名
    • Organizer
      東海乳酸菌研究会
    • Place of Presentation
      中日パレス(愛知県)
    • Year and Date
      2012-02-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] A群レンサ球菌csrS遺伝子の変異と菌の病原性に関する研究2012

    • Author(s)
      立野一郎
    • Organizer
      日本細菌学会・中部支部総会
    • Place of Presentation
      金沢大学医学類十全講堂 (石川県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] S. pyogenes 二成分制御因子SPY1622の酸感受性およびバイオフィルム形成の作用機序について2012

    • Author(s)
      井坂雅徳
    • Organizer
      第21回Lancefield レンサ球菌研究会
    • Place of Presentation
      大阪大学吹田キャンパス内、歯学研究科、弓倉記念ホール(大阪府)
    • Related Report
      2012 Annual Research Report
  • [Presentation] A群レンサ球菌における二成分制御系因子の解析2011

    • Author(s)
      立野一郎
    • Organizer
      日本細菌学会・中部支部総会
    • Place of Presentation
      名古屋大学(愛知県)
    • Year and Date
      2011-10-21
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 劇症型A群連鎖球菌NAD-glycohydrolaseとMタンパク質のマウスへの経鼻投与による抗原性及び防御効果2010

    • Author(s)
      井坂雅徳、立野一郎, (他4名)
    • Organizer
      日本細菌学会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2019-07-29  

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