In vivo suppression of the toxicity in the invasive M-1 group A Streptococcal isolates
| Project/Area Number |
21790425
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Nagoya City University |
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Principal Investigator |
TATSUNO Ichiro 名古屋市立大学, 大学院・医学研究科, 講師 (50311642)
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| Project Period (FY) |
2009 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | A 群連鎖球菌 / A 群レンサ球菌 / 人喰いバクテリア / レンサ球菌 / 連鎖球菌 / NADase / LPS / 蛍光 / Nga / IFS |
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| Research Abstract |
I have studied about in vivo suppression of the toxicity in the invasive M-1 group A Streptococcal isolates, using mouse infection model. As results
(1) I could partially suppressed the toxicity in an invasive M-1 group A Streptococcal isolate, suppressing the NADase activity of Nga protein which is secreted toxin;
(2) I have presented the supportive evidence that Nga (also known as SPN) has a NADase-independent function;
(3) I provided other potential targets to suppress the Streptococcal virulence.
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Report
(5 results)
Research Products
(27 results)
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[Journal Article] Detection of invasive protein profile of Streptococcus pyogenes M1 isolates from pharyngitis patients2010
Author(s)
Hasegawa T, Okamoto A, Kamimura T, Tatsuno I, Hashikawa S, Yabutani M, Matsumoto M, Yamada K, Isaka M, Minami M, Ohta M
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Journal Title
APMIS
Volume: 118
Issue: 3
Pages: 167-78
DOI
Related Report
Peer Reviewed
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