Helicobacter heilmannii infection and gastric MALT lymphoma

• Project/Area Number: 21790427
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Bacteriology (including Mycology)
• Research Institution: Kitasato University
• Principal Investigator: SEKIYA Yukie 北里大学, 北里生命科学研究所, 研究員 (10414054)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: Helicobacter heilmannii / 胃MALTリンパ腫 / ヘリコバクター / 消化器疾患 / バイオプシー / 組織化学 / リアルタイムPCR / プロバイオティクス / マウス感染モデル / PCR / マイクロアレイ / 胃バイオプシー / 16SrRNA遺伝子 / 鳥肌胃炎

Research Abstract

In this case study conducted in Tokyo metropolitan area, it was revealed that the infection rates of H. pylori and H. heilmannii in upper gastrointestinal tract diseases were 73.9% and 1.1%, respectively(total 1, 045 patients). However, on the restricted patients suffering from gastric MALT lymphoma, the infection rate of H. heilmannii was 25%. Besides, 20% patients in the H. heilmannii-infected were coinfected with H. pylori.

Research Products

• [Journal Article] Darmal mast cells reduce progressive tissue necrosis caused by subcutaneous infection with Streptococcus pyogenes in mice (2011)
  • Author(s): Hidenori Matsui, Yukie Sekiya, Tetsufumi Takahashi, Masahiko Nakamura, Ken'ichi Imanishi, Haruno Yoshida, Somay Yamagata Murayama, Takashi Takahashi, Kanji Tsuchimoto, Takehiko Uchiyama, and Kimiko Ubukata
  • Journal Title: Journal of Medical Microbiology Volume: 60(1) Pages: 128-134
• [Journal Article] Darmal mast cells reduce progressive tissue necrosis caused by subcutaneous infection with Streptococcus pyogenes in mice. (2011)
  • Author(s): Hidenori Matsui, Yukie Sekiya, Tetsufumi Takahashi, Masahiko Nakamura, Ken'ichi Imanishi, Haruno Yoshida, Somay Yamagata Murayama, Takashi Takahashi, Kanji Tsuchimoto, Takehiko Uchiyama, Kimiko Ubukata.
  • Journal Title: Journal of Medical Microbiology Volume: 60 Pages: 128-134
  • Peer Reviewed
• [Journal Article] Candidatus Helicobacter heilmannii infection in the course of gastric mucosa-associated lymphoid tissue(MALT) lymphoma in human beings and mouse models (2010)
  • Author(s): Hidenori Matsui, Yukie Sekiya, Chihiro Aikawa, Somay Yamagata Murayama, Tetsufumi Takahashi, Haruno Yoshida, Takashi Takahashi, Kanji Tsuchimoto, and Masahiko Nakamura
  • Journal Title: Current Trends in Microbiology Volume: 6 Pages: 27-34
• [Journal Article] Candidatus Helicobacter heilmannii" infection in the course of gastric mucosa-associated lymphoid tissue (MALT) lymphoma in human beings and mouse models. (2010)
  • Author(s): Hidenori Matsui, Yukie Sekiya, Chihiro Aikawa, Soamy Yamagata Murayama, Tetsufumi Takahashi, Haruno Yoshida, Takashi Takahashi, Kanji Tsuchimoto, Masahiko Nakamura.
  • Journal Title: Current Trends in Microbiology Volume: 6 Pages: 1-8
  • Peer Reviewed
• [Journal Article] CD46 transgenic mouse model of necrotizing fasciitis caused by Streptococcus pyogenes infection (2009)
  • Author(s): Hidenori Matsui, Yukie Sekiya, Masahiko Nakamura, Somay Yamagata Murayama, Haruno Yoshida, Tetsufumi Takahashi, Ken'ichi Imanishi, Kanji Tsuchimoto, Takehiko Uchiyama, Keinosuke Sunakawa, and Kimiko Ubukata
  • Journal Title: Infection and Immunity Volume: 77(11) Pages: 4806-4814
• [Journal Article] 熱応答性磁性ナノ粒子を用いた細菌分離法 (2009)
  • Author(s): 高橋哲史、松井英則、関谷幸江、中村正彦、土本寛二
  • Journal Title: Progress in Medicine Volume: 29(3) Pages: 751-754
• [Journal Article] CD46 transgenic mouse model of necrotizing fasciitis caused by Streptococcus pyogenes infection. (2009)
  • Author(s): Matsui, H., et al.
  • Journal Title: Infection and Immunity 77 Pages: 4806-4814
  • Peer Reviewed
• [Presentation] Detection of Helicobacter heilmannii DNA in gastric biopsy specimens by PCR in Japan (2012)
  • Author(s): 関谷幸江、中谷百合子、吉田春乃、村山そう明、中村正彦、松井英則
  • Organizer: 第85回日本細菌学会総会
  • Place of Presentation: 長崎ブリックホール
  • Year and Date: 2012-03-28
• [Presentation] Osteonecrosis in CD46 Tg mice caused by Spyogenes infection is T cell-derived RANKL independent (2012)
  • Author(s): 中谷百合子、松井英則、吉田春乃、関谷幸江、村山そう明、中村正彦、生方公子
  • Organizer: 第85回日本細菌学会総会
  • Place of Presentation: 長崎ブリックホール
  • Year and Date: 2012-03-28
• [Presentation] CD46TgマウスへのA群レンサ球菌感染により誘導される骨壊死はT細胞由来のRANKLに依存しない (2012)
  • Author(s): 中谷百合子、松井英則、吉田春乃、関谷幸江、村山そう明、中村正彦、生方公子
  • Organizer: 85回日本細菌学会総会
  • Place of Presentation: 長崎ブリックホール・長崎新聞分化ホール
  • Year and Date: 2012-03-27
• [Presentation] 日本におけるPCR法を用いた胃生検体からのHelicobacter heilmannii DNAの検出 (2012)
  • Author(s): 関谷幸江、中谷百合子、吉田春乃、村山そう明、中村正彦、松井英則
  • Organizer: 85回日本細菌学会総会
  • Place of Presentation: 長崎ブリックホール・長崎新聞分化ホール
• [Presentation] Helicobacter heilmannii感染による胃MALTリンパ腫病態形成時における宿主遺伝子発現の解析 (2011)
  • Author(s): 高橋哲史, 中村正彦, 松井英則, 関谷幸江, 土本寛二
  • Organizer: 39回日本潰瘍学会
  • Place of Presentation: つくば国際会議場
  • Year and Date: 2011-11-18
• [Presentation] Helicobacter heilmannii感染による胃MALTリンパ腫病態形成時における宿主遺伝子発現の解析 (2011)
  • Author(s): 高橋哲史, 中村正彦, 松井英則, 関谷幸江, 土本寛二
  • Organizer: 第39回日本潰瘍学会
  • Place of Presentation: つくば国際会議場
  • Year and Date: 2011-11-18
• [Presentation] Gastric MALT lymphomas in mice infected with HHLO from a patient with nodular gastritis (2010)
  • Author(s): Tetsufumi Takahashi, Hidenori Matsui, Yukie Sekiya, Haruno Yoshida, Somay Murayama, and Masahiko Nakamura
  • Organizer: 第83回日本細菌学会総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2010-03-27
• [Presentation] Protective roles of skin mast cells in mouse models of necrotizing fasciitis caused by GAS infection (2010)
  • Author(s): Haruno Yoshida, Hidenori Matsui, Yukie Sekiya, Ken'ichi Imanishi, Tetsufumi Takahashi, Somay Murayama, Masahiko Nakamura, Takehiko Uchiyama, and Kimiko Ubukata
  • Organizer: 第83回日本細菌学会総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2010-03-27
• [Presentation] Gastric MALT lymphomas in mice in fected with HHLO from a patient with nodular gastritis (2010)
  • Author(s): Takahashi, T., at al.
  • Organizer: 第83回日本細菌学会総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2010-03-27
• [Presentation] ヒトCD46発現マウスを用いた実験的劇症型A群溶血性レンサ球菌感染症の解析 (2009)
  • Author(s): 松井英則、関谷幸江、中村正彦、高橋哲史、村山そう明、内山竹彦、砂川慶介、生方公子
  • Organizer: 第83回日本感染症学会総会
  • Place of Presentation: 京王プラザホテル
  • Year and Date: 2009-04-23
• [Presentation] ヒトCD46発現マウスを用いた実験的劇症型A群溶血性レンサ球菌感染症の解析 (2009)
  • Author(s): 松井英則, 他
  • Organizer: 第83回日本感染症学会総会
  • Place of Presentation: 京王プラザホテル(東京)
  • Year and Date: 2009-04-23
• [Presentation] Maturation of Fundic Glandular Cells are Markedly Altered in IL-10(-/-) mice (2009)
  • Author(s): Takahashi, T., et al.
  • Organizer: 13th Taisho-Toyama International Symposium on Gastroenterology
  • Place of Presentation: 下田
  • Year and Date: 2009-04-17
• [Presentation] Maturation of Fundic Glandular Cells are Markedly Altered in IL-10(-/-) mice (2009)
  • Author(s): Tetsufumi Takahashi, Masahiko Nakamura, Hidenori Matsui, Yukie Sekiya, Nobuhiko Kamada, Toshifumi Hibi, Kanji Tsuchimoto
  • Organizer: 13th Taisho-Toyama International Symposium on Gastroenterology
  • Place of Presentation: Shimoda, Japan
  • Year and Date: 2009-04-16