| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
Gram-negative pathogenic bacteria, such as Shigella secrete various virulence factors into a host cell for efficient and continuous infection. This research suggested that virulence factors have two opposite functions, which are to enhance or to inhibit destruction of an epithelial cell. They control rapid destruction of an infected cell by modifying the cell signal pathway. These results provide clues as to the underlying cause of enteric infection and is expected to contribute to infection control measures, such as treatment of infection and development of vaccine.
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