| Project/Area Number |
21790434
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Bacteriology (including Mycology)
|
|---|
| Research Institution | National Institute of Infectious Diseases |
|---|
Principal Investigator |
IYODA Sunao National Institute of Infectious Diseases, 細菌第一部, 主任研究官 (70300928)
|
|---|
| Research Collaborator |
本田 尚子 東京大学, 大学院・医学系研究科, 博士後期課程大学院生
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Keywords | 腸管出血性大腸菌 / 発現制御 / LEE / 3型蛋白質輸送装置 |
|---|
| Research Abstract |
The transcription of LEE genes in EHEC is under the positive control of PchABC, which are encoded by the genes dispersed on the chromosome. We identified transcriptional start sites and promoter sequences of each gene. Genetic analysis using transposon mutagenesis identified that a LysR-type regulator, LrhA positively controls LEE gene expression through the transcriptional up-regulation of pchA and pchB.
|
