Screening for a new meningococcal pathogenic factor by STM
| Project/Area Number |
21790435
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 感染症 / 微生物 / 髄膜炎菌 / Neisseria meningitidis / 病原因子 / Signature Tag Mutagenesis / トランスポゾン変異 / 変異株 / signature tag mutagenesis |
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| Research Abstract |
I constructed a transposon-inserted meningococcal mutant library by STM and screened adhesion or invasion-defective mutants to human brain microvasocular endothelial cells. By the 5th steps of screening, 31 mutants were finally selected.
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Report
(4 results)
Research Products
(13 results)
