Elucidation of mechanism for polarized regulation of viral RNA synthesis of negative-strand RNA viruses
| Project/Area Number |
21790447
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Virology
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| Research Institution | Hiroshima University |
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Principal Investigator |
IRIE Takashi Hiroshima University, 大学院・医歯薬学総合研究科, 准教授 (70419498)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ウイルスRNA合成 / (-)鎖RNAウイルス / ウイルス / 感染症 / バイオテクノロジー |
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| Research Abstract |
In this study aimed at elucidation of mechanism of polarized regulation of viral RNA synthesis, which should be required for efficient viral replication, we found that the C protein, one of the accessory protein of Sendai virus, a prototype of negative-stranded viruses, down-regulated (+)-sense viral RNA synthesis in a time-dependent manner and maximized production of infectious progeny virions. In addition, in the course of this study, we also found a possibility that the C protein regulate viral RNA synthesis to escape from detection by host innate immunity.
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Report
(3 results)
Research Products
(32 results)
