| Project/Area Number |
21790453
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Virology
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
TERAHARA Kazutaka National Institute of Infectious Diseases, 免疫部, 研究員 (50469954)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 感染防御 / ワクチン / ウイルス / 免疫学 / サルモネラ / HIV / 腸管 |
|---|
| Research Abstract |
In this study, we aimed to elucidate the mechanism by which human immunodeficiency virus (HIV)-specific cytotoxic T lymphocytes (CTLs) are induced in the intestine. HIV-1 Gag-expressing Salmonella typhimurium aroA- or aroA-invAmutants, which can or not, respectively, penetrate Peyer's patches, were used as oral antigens into mice. However, Gag-specific CTLs were hardly induced in both the systemic and the gut mucosal compartments. Further study should be needed for better understanding of the role of Peyer's patches in the induction of mucosal CTLs.
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