Regulation of cytotoxic T lymphocyte activities by MHC class I-binding receptors.

• Project/Area Number: 21790458
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Immunology
• Research Institution: Tohoku University
• Principal Investigator: ENDO Shota Tohoku University, 加齢医学研究所, 助教 (70466580)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 免疫制御 / 移植免疫 / 腫瘍免疫 / 細胞傷害性T細胞 / 樹状細胞 / 免疫学 / がん / ウイルス / 移植 / 癌

Research Abstract

MHC class I-binding receptors regulate cytotoxic T lymphocyte activities, which cells are indispensable in controlling tumor and transplant rejection. In this study, I have clarified the molecular mechanism of the regulation system controlled by the MHC class I-binding receptors. The findings will provide a novel strategy for regulating cytotoxic T lymphocyte-mediated immunity and diseases.

Research Products

• [Journal Article] Transcriptional activation of the Pirb gene in B cells by PU.1 and Runx3. (2011)
  • Author(s): Kojo Arita, Shota Endo, Tomonori Kaifu, Kohji Kitaguchi, Akira Nakamura, Hidetaka Ohmori, Kazuyoshi Kohu, Masanobu Satake, Toshiyuki Takai.
  • Journal Title: J.Immunol. in press.
  • Peer Reviewed
• [Journal Article] Myelin suppresses axon regeneration by PIR-B/SHP-mediated inhibition of Trk activity. (2011)
  • Author(s): Yuki Fujita, Shota Endo, Toshiyuki Takai, Toshihide Yamashita.
  • Journal Title: EMBO J. 30 Pages: 1389-1401
  • Peer Reviewed
• [Journal Article] Myelin suppresses axon regeneration by PIR-B/SHP-mediated inhibition of Trk activity. (2011)
  • Author(s): Fujita Y, Endo S.Takai T, Yamashita T.
  • Journal Title: EMBO Journal Volume: (In press)
  • Peer Reviewed
• [Journal Article] Ectopically expressed PIR-B on T cells constitutively binds to MHC class I and attenuates T helper type 1 responses (2009)
  • Author(s): Michiyo Imada, Kyoko Masuda, Rumi Satoh, Yumi Ito, Yoshiyuki Goto, Takayuki Matsuoka, Shota Endo, Akira Nakamura, Hiroshi Kawamoto, Toshiyuki Takai
  • Journal Title: International Immunology Vol.21 Pages: 1151-1161
  • NAID: 10027389800
  • Peer Reviewed
• [Presentation] PIR-BによるNogo/MHCクラスI認識の相違性に基づくマスト細胞の新しい制御機構 (2010)
  • Author(s): 遠藤章太, 北口公司, 中村晃, 高井俊行
  • Organizer: 日本アレルギー学会秋期学術大会
  • Place of Presentation: 東京
  • Year and Date: 2010-11-25
• [Presentation] Regulation of cytotoxic T lymphocyte activity by CD8 and PIR-B. (2010)
  • Author(s): Shota Endo, Yuzuru Sakamoto, Eiji Kobayashi, Akira Nakamura, Toshiyuki Takai.
  • Organizer: The 5th International Symposium of Institute Network.
  • Place of Presentation: Kanazawa.
  • Year and Date: 2010-06-24
• [Presentation] Regulation of cytotoxic T lymphocyte activity by CD8 and PIR-B. (2010)
  • Author(s): Endo S, Sakamoto Y, Kobayashi E, Nakamura A, Takai T.
  • Organizer: The 5th International Symposium of Institute Network.
  • Place of Presentation: Kanazawa
  • Year and Date: 2010-06-24
• [Presentation] Regulation of cytotoxic T lymphocyte activity by PIR-B expressed on dendritic cells (2009)
  • Author(s): Shota Endo, Akira Nakamura, Toshiyuki Takai
  • Organizer: The 9th World Congress on Inflammation
  • Place of Presentation: Keio Plaza Hotel(Tokyo)
  • Year and Date: 2009-07-07