Regulation of cytotoxic T lymphocyte activities by MHC class I-binding receptors.
Project/Area Number |
21790458
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Immunology
|
Research Institution | Tohoku University |
Principal Investigator |
ENDO Shota Tohoku University, 加齢医学研究所, 助教 (70466580)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | 免疫制御 / 移植免疫 / 腫瘍免疫 / 細胞傷害性T細胞 / 樹状細胞 / 免疫学 / がん / ウイルス / 移植 / 癌 |
Research Abstract |
MHC class I-binding receptors regulate cytotoxic T lymphocyte activities, which cells are indispensable in controlling tumor and transplant rejection. In this study, I have clarified the molecular mechanism of the regulation system controlled by the MHC class I-binding receptors. The findings will provide a novel strategy for regulating cytotoxic T lymphocyte-mediated immunity and diseases.
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Report
(3 results)
Research Products
(8 results)