A novel molecule that regulates T-cell tolerance under PD-1.

• Project/Area Number: 21790465
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Immunology
• Research Institution: Kyoto University
• Principal Investigator: CHIKUMA Shunsuke Kyoto University, 医学研究科, 助教 (50437208)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 免疫寛容 / 自己免疫 / 免疫抑制受容体 / 免疫学 / 自己免疫疾患 / がん免疫 / 免疫制御

Research Abstract

ITAG-1 was first identified as a novel molecule that was uniquely suppressed by PD-1 mediated inhibitory signal in T-cells. Analyses using newly generated ITAG-1 knockout mice revealed ITAG-1's role in the terminal development of cytotoxic T-cells. Although, the precise mechanism is still under investigation, current data suggested PD-1 mediated modulation of ITAG-1 expression is involved in T cell activation, differentiation and tolerance.

Research Products

• [Journal Article] (*Equal contribution) IFN-alpha directly promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity (2011)
  • Author(s): Terawaki S, Chikuma S, Shibayama S, et al
  • Journal Title: J Immunol Vol.186 Pages: 2772-2779
  • Peer Reviewed
• [Journal Article] IFN-alpha directly promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity. (2011)
  • Author(s): Terawaki S, Chikuma S, Shibayama S, et al.(Equal contribution)
  • Journal Title: The Journal of Immunology Volume: 186 Pages: 2772-2779
  • Peer Reviewed
• [Journal Article] (Chikuma S is the 4th out of 9 authors) PD-1 deficiency results in the development of fatal myocarditis in MRL mice (2010)
  • Author(s): Wang J, et al
  • Journal Title: Int Immunol Vol.22 Pages: 443-452
  • Peer Reviewed
• [Journal Article] PD-1 deficiency results in the development of fatal myocarditis in MRL mice. (2010)
  • Author(s): Wang J, et al.
  • Journal Title: International Immunology Volume: 22 Pages: 443-452
  • Peer Reviewed
• [Journal Article] Honjo T PD-1-mediated suppression of IL-2 production induces CD8+ T cell anergy in vivo (2009)
  • Author(s): Chikuma S, Terawaki S, Hayashi T, Nabeshima R, Yoshida T, Shibayama S, Okazaki T
  • Journal Title: J.Immunol Vol.182 Pages: 6682-6689
  • Peer Reviewed
• [Presentation] Type I interferon promotes programmed cell death-1 transcription and limits the duration of T cell-mediated immunity (2011)
  • Author(s): Shunsuke Chikuma
  • Organizer: 98th Annual Meeting, The American Association of Immunologists
  • Place of Presentation: San Francisco, U.S.A.
• [Presentation] In search of molecules that regulate PD-1 mediated inhibition of T cell function (2010)
  • Author(s): Shunsuke Chikuma
  • Organizer: 14th International congress of Immunology
  • Place of Presentation: Kobe, Japan
• [Presentation] In search of molecules that regulate PD-1 mediated inhibition of T cell function. (2010)
  • Author(s): Shunsuke Chikuma
  • Organizer: 14^<th> International congress of Immunology Aug 23-27, 2010
  • Place of Presentation: 神戸