Analysis of the role of cytoplasmictail in IgG molecule for the development and the sustention of memory B cells

Research Project

Project/Area Number	21790466
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Immunology
Research Institution	Kyoto University
Principal Investigator	TODO Kagefumi Kyoto University, 医学研究科, 特定研究員 (50452561)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	免疫記憶 / 免疫学 / B細胞 / 抗原受容体
Research Abstract	The IgG molecule expressing on the memory B cells have the evolutionarily conserved cytoplasmic tail. However, the physiological role of the IgG cytoplasmic tail is not clear. Therefore, the purpose of this study was to clarify the role of the cytoplasmic tail of IgG molecule. As a result, the cytoplasmic tail of IgG contributed to the stably expression of the IgG molecule on the cell surface, and its phosphorylation contributed to more stably expression of the IgG on the cell surface.

Report

(3 results)