Analysis of the role of cytoplasmictail in IgG molecule for the development and the sustention of memory B cells
| Project/Area Number |
21790466
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Immunology
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
TODO Kagefumi Kyoto University, 医学研究科, 特定研究員 (50452561)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 免疫記憶 / 免疫学 / B細胞 / 抗原受容体 |
|---|
| Research Abstract |
The IgG molecule expressing on the memory B cells have the evolutionarily conserved cytoplasmic tail. However, the physiological role of the IgG cytoplasmic tail is not clear. Therefore, the purpose of this study was to clarify the role of the cytoplasmic tail of IgG molecule.
As a result, the cytoplasmic tail of IgG contributed to the stably expression of the IgG molecule on the cell surface, and its phosphorylation contributed to more stably expression of the IgG on the cell surface.
|
Report
(3 results)
Research Products
(3 results)
