| Project/Area Number |
21790468
|
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
|
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| Research Institution | Keio University (2010)
Osaka University (2009) |
|---|
Principal Investigator |
KIMURA Akihiro Keio University, 医学部, 助教 (20533318)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | Ahr / LPS / マクロファージ / 関節リウマチ / 自然免疫 / ダイオキシン受容体 / リステリア / IL-6 |
|---|
| Research Abstract |
Ahr is induced in macrophages stimulated by LPS. The production of IL-6 and tumor necrosis factor (TNF)-α by LPS was significantly elevated in Ahr-deficient macrophages compared to that in wild-type (WT) cells. Ahr forms a complex with Stat1 and nuclear factor-kappa B (NF-κB) in macrophages stimulated by LPS, which leads to inhibition of the promoter activity of IL-6. Ahr thus plays an essential role in the negative regulation of the LPS signaling pathway through interaction with Stat1. In dendritic cells, Ahr induces the expression of IDO, which promotes Treg cell differentiation.
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