Re-education of T cells in the thymus
| Project/Area Number |
21790472
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Immunology
|
|---|
| Research Institution | The University of Tokushima |
|---|
Principal Investigator |
NITTA Takeshi The University of Tokushima, 疾患ゲノム研究センター, 講師 (30373343)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 胸腺 / T細胞 / 髄質 / 免疫寛容 / 自己免疫 / 髄質上皮細胞 / RANKL |
|---|
| Research Abstract |
The thymus is an organ that supports development and education of T cells, which play a central role in the immune system. The thymic medulla is essential for the deletion of auto-reactive immature T cells, preventing autoimmunity. Here we show that, with mice in that thymic medulla is genetically enlarged, peripheral T cells efficiently re-enter the thymic medulla. These re-entered T cells contained activated T cells and regulatory T cells, suggesting the possibility that peripheral T cells are "re-educated" in the thymic medulla.
|
Report
(3 results)
Research Products
(22 results)
-
[Journal Article] Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development.2011
Author(s)
Lei, Y., Mat Ripen, A., Ishimaru, N., Ohigashi, I., Nagasawa, T., Jeker, L.T., Bosl, M.R., Hollander, G.A., Hayashi, Y., de Waal Malefyt, R., Nitta, T., Takahama, Y.
-
Journal Title
J Exp Med 208
Pages: 383-394
Related Report
Peer Reviewed
-
[Journal Article] Ex-vivo expanded DC induce donor-specific central and peripheral tolerance and prolong the acceptance of donor skin allografts.2011
Author(s)
Yamano, T., Watanabe, S., Hasegawa, H., Suzuki, T., Abe, R., Tahara, H., Nitta, T., Ishimaru, N., Sprent, J., Kishimoto, H.
-
Journal Title
Blood 117
Pages: 2640-2648
Related Report
Peer Reviewed
-
-
-
-
-
[Journal Article] Lymphotoxin signals from positively selected thymocytes regulate the terminal differentiation of medullary thymic epithelial cells.2010
Author(s)
White, A.J., Nakamura, K., Jenkinson, W.E., Saini, M., Sinclair, C., Seddon, B., Narendran, P., Pfeffer, K., Nitta, T., Takahama, Y., Caamano, J.H., Lane, P.J.L., Jenkinson, E.J., Anderson, G.
-
Journal Title
J Immunol 185
Pages: 4769-4776
Related Report
Peer Reviewed
-
[Journal Article] In situ Patrolling of Regulatory T cells is Essential for Protecting Autoimmune Exocrinopathy.2010
Author(s)
Ishimaru, N., Nitta, T., Arakaki, R., Yamada, A., Lipp, M., Takahama, Y.Hayashi, Y.
-
Journal Title
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
